104371-21-3

Basic information

• Product Name: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL
• Synonyms: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL;R(+)-ALPHA-METHYL-2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL;(R)-(+)-1-(PENTAFLUOROPHENYL)ETHANOL, FL UKABRAND CHIRASELECT REAGENT, 99+%;(r)-(+)-α-methyl-2,3,4,5,6-pentafluorobenzyl alcohol;(1R)-1-(Pentafluorophenyl)ethanol
• CAS NO: 104371-21-3
• Molecular Formula: C₈H₅F₅O
• Molecular Weight: 212.12
• Mol File: 104371-21-3.mol
• Article Data: 17

Chemical Properties

• Melting Point: 41-42 °C(lit.)
• Flash Point: 189 °F
• Appearance: /
• BRN: 5268492
• CAS DataBase Reference: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL(104371-21-3)
• EPA Substance Registry System: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL(104371-21-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 104371-21-3(Hazardous Substances Data)

Upstream product

• 652-29-9 2',3',4',5',6'-pentafluoroacetophenone 
• 344-04-7 bromopentafluorobenzene 
• 108-22-5 Isopropenyl acetate 
• 830-50-2 1-(pentafluorophenyl)ethanol 
• 108-05-4 vinyl acetate 
• 653-37-2 perfluorobenzaldehyde 
• 544-97-8 dimethyl zinc(II) 

Relevant articles and documents

Enantioselectivity in the Noyori?Ikariya asymmetric transfer hydrogenation of ketones

Asymmetric transfer hydrogenation (ATH) is an important catalytic process in the fragrance and pharmaceutical industries. The Noyori?Ikariya chiral molecular ruthenium complex has been the catalyst of choice for this reaction for over 25 years. The mechan

One-pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation

Enantiomerically enriched chiral secondary alcohols serve as valuable building blocks for drug intermediates and fine chemicals. In this study the deracemisation of secondary alcohols to generate enantiomeric pure chiral alcohols has been achieved by combining enantio-selective enzymatic oxidation of a secondary alcohol, by a variant of GOase (GOase M3-5), with either non-selective ketone reduction via transfer hydrogenation (TH) or enantio-selective asymmetric transfer hydrogenation (ATH). Both the enzymatic oxidation system and the transition-metal mediated reduction system were optimised to ensure compatibility with each other resulting in a homogeneous reaction system. 1-(4-nitrophenyl)ethanol was generated with 99 % conversion and 98 % ee by the deracemisation method, and it has been extended to a series of other secondary alcohols with comparable results.

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.