830-50-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(PENTAFLUOROPHENYL)ETHANOL, 97 is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its presence in the molecular structure facilitates the creation of new compounds with potential therapeutic applications.
Used in Organic Compound Synthesis:
In the field of organic chemistry, 1-(PENTAFLUOROPHENYL)ETHANOL, 97 is utilized as a building block for the synthesis of a range of organic compounds. Its ability to participate in reactions requiring both phenyl and alcohol groups makes it a valuable component in the development of new chemical entities.
Used in Fine Chemicals Production:
1-(PENTAFLUOROPHENYL)ETHANOL, 97 is employed as a versatile reagent in the preparation of intermediates for fine chemicals. Its unique properties allow for the creation of high-quality specialty chemicals used across various industries.
Used in Research and Development:
In the realm of scientific research and development, 1-(PENTAFLUOROPHENYL)ETHANOL, 97 serves as a crucial component in experiments and the development of new methodologies, contributing to advancements in organic synthesis and related fields.

Upstream product

• 653-34-9 2,3,4,5,6-pentafluorostyrene 
• 897049-54-6 2-(1-pentafluorophenyl-ethyl)-benzo[1,3,2]dioxaborole 
• 879-06-1 pentafluorophenylmagnesium chloride 
• 75-07-0 acetaldehyde 
• 652-29-9 2',3',4',5',6'-pentafluoroacetophenone 
• 392-56-3 Hexafluorobenzene 
• 79-33-4 L-Lactic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 879-05-0 2,3,4,5,6-pentafluorophenylmagnesium bromide 
• 363-72-4 Pentafluorobenzene 
• 64-17-5 ethanol 

Downstream Products

• 653-34-9 2,3,4,5,6-pentafluorostyrene 
• 66286-18-8 dl-1-(2,3,4,5-tetrafluorophenyl)ethanol 
• 104291-40-9 (1'R)-N-(1'-Phenylethyl)carbamidsaeure-<(1S)-1-(pentafluorphenyl)ethylester> 
• 104291-40-9 (1'R)-N-(1'-Phenylethyl)carbamidsaeure-<(1R)-1-(pentafluorphenyl)ethylester> 
• 32019-38-8 (+/-)-1-(2,3,4,5,6-pentafluorophenyl)ethyl acetate 
• 40395-04-8 α-Pentafluorphenylethyl-triphenylmethyl-ether 
• 5576-26-1 1-Chlor-1--ethan 
• 178879-75-9 N-<(+/-)-1'-(2'',3'',4'',5'',6''-Pentafluorophenyl)ethyl>succinimide 
• 104371-20-2 (S)-1-(2',3',4',5',6'-perfluorophenyl)ethanol 
• 104371-21-3 (R)-(+)-1-(pentafluorophenyl)ethanol 
• 862731-95-1 2-[1-(2,3,4,5,6-pentafluorophenyl)ethoxy]-1,3,2-benzodioxaphospholene 
• 715-35-5 (1,2-dibromo-ethyl)-pentafluoro-benzene 
• 652-29-9 2',3',4',5',6'-pentafluoroacetophenone 

Relevant academic research and scientific papers

Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids

Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with bro

One-pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation

Enantiomerically enriched chiral secondary alcohols serve as valuable building blocks for drug intermediates and fine chemicals. In this study the deracemisation of secondary alcohols to generate enantiomeric pure chiral alcohols has been achieved by combining enantio-selective enzymatic oxidation of a secondary alcohol, by a variant of GOase (GOase M3-5), with either non-selective ketone reduction via transfer hydrogenation (TH) or enantio-selective asymmetric transfer hydrogenation (ATH). Both the enzymatic oxidation system and the transition-metal mediated reduction system were optimised to ensure compatibility with each other resulting in a homogeneous reaction system. 1-(4-nitrophenyl)ethanol was generated with 99 % conversion and 98 % ee by the deracemisation method, and it has been extended to a series of other secondary alcohols with comparable results.

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.

Asymmetric Magnesium-Catalyzed Hydroboration by Metal-Ligand Cooperative Catalysis

Asymmetric catalysis with readily available, cheap, and non-toxic alkaline earth metal catalysts represents a sustainable alternative to conventional synthesis methodologies. In this context, we describe the development of a first MgII-catalyzed enantioselective hydroboration providing the products with excellent yields and enantioselectivities. NMR spectroscopy studies and DFT calculations provide insights into the reaction mechanism and the origin of the enantioselectivity which can be explained by a metal-ligand cooperative catalysis pathway involving a non-innocent ligand.

C(sp2)-F Oxidative Addition of Fluorinated Aryl Ketones by iPrPCPIr

The reaction of iPrPCPIrH4 (iPrPCP = κ3-2,6-C6H3(CH2P(iPr)2)2) with ≥2 equiv of 2,3,4,5,6-pentafluoroacetophenone (AP-F5) in aromatic solvents at

Synthetic method for optical pure penta-fluo-phenethyl alcohol

The invention relates to resolution of a phenethyl alcohol compound and especially relates to a synthetic method for optical pure penta-fluo-phenethyl alcohol, mainly aiming at solving the technical problems of long synthetic route of a penta-fluo-phenethyl alcohol asymmetric synthesis method and industrial use limitation of an enzymolysis resolution method. According to the technical scheme provided by the invention, the synthetic method for optical pure penta-fluo-phenethyl alcohol comprises the following steps: reducing pentafluoroacetophenone with sodium borohydride, reacting with phthalic anhydride to generate a benzoic acid derivative, and then chemically resolving the benzoic acid derivative with chiral phenylethylamine, removing phenylethylamine with diluted hydrochloric acid, resolving the phthalic acid group with alkali, extracting, drying, filtering and concentrating, thereby acquiring the optical pure penta-fluo-phenethyl alcohol product.

Nickel-catalyzed reduction of ketones with water and triethylsilane

The acetophenone (1a) reduction using catalytically active nickel complexes and water is an efficient and sustainable method to access a new methodology of transfer hydrogenation of ketones. When triethylsilane (Et3SiH) was used as sacrificial agent to promote the transfer hydrogenation from water, 1-phenylethanol (2a) was obtained in excellent yield along with silanol (Et3SiOH) as the reaction's driving force. Deuterium labeling studies were made using Et3SiD or D2O and these studies showed that both compounds participate as hydride sources for the ketone reduction. A scope of substrates was assessed, including a variety of mono/diketones, and α,β-unsaturated ketones, to yield the corresponding secondary alcohols and saturated ketones. Additionally, asymmetric transfer hydrogenation of mono-ketones was studied for the mixture of nickel/(bisphosphine or phospholane) as catalyst precursor, using H2O/Et3SiO system and ethanol as hydrogen sources.

Nickel-catalyzed transfer hydrogenation of ketones using ethanol as a solvent and a hydrogen donor

We report a nickel(0)-catalyzed direct transfer hydrogenation (TH) of a variety of alkyl-aryl, diaryl, and aliphatic ketones with ethanol. This protocol implies a reaction in which a primary alcohol serves as a hydrogen atom source and solvent in a one-pot reaction without any added base. The catalytic activity of the nickel complex [(dcype)Ni(COD)] (e) (dcype: 1,2-bis(dicyclohexyl-phosphine)ethane, COD: 1,5-cyclooctadiene), towards transfer hydrogenation (TH) of carbonyl compounds using ethanol as the hydrogen donor was assessed using a broad scope of ketones, giving excellent results (up to 99% yield) compared to other homogeneous phosphine-nickel catalysts. Control experiments and a mercury poisoning experiment support a homogeneous catalytic system; the yield of the secondary alcohols formed in the TH reaction was monitored by gas chromatography (GC) and NMR spectroscopy.

Cyclopentadienyliron dicarbonyl dimer: A simple tool for the hydrosilylation of aldehydes and ketones under air

The readily available iron complex [CpFe(CO)2]2 (1) exhibits good catalytic activity in the hydrosilylation of aldehydes and ketones in the presence of diethoxymethylsilane. The procedure described is air-tolerant and applicable to a wide range of substrates.

Hydrodefluorination of Fluoroarenes Using Hydrogen Transfer Catalysts with a Bifunctional Iridium/NH Moiety

The hydrodefluorination of fluoroarenes with transfer hydrogenation catalysts using 2-propanol or potassium formate is described. With the aid of metal/NH cooperation, the C-N chelating Ir complexes derived from benzylic amines can efficiently promote the reduction involving the C-F bond cleavage under ambient conditions even in the absence of hydrosilanes or H2 gas, leading to the partially fluorinated products in good yields and with high selectivity.