104373-96-8Relevant articles and documents
Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes
Deng, Ling,Hu, Jinbo,Ni, Chuanfa,Zhou, Xin
supporting information, p. 8750 - 8753 (2021/09/08)
Radical fluoroalkylation of alkenes has been developed by electrochemical reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily undergo hydrofluoroalkylation in good to excellent yields. This chemistry represents the first example of electrochemical generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds.
1-(2-Pyridinyl)piperazine Derivatives with Antianaphylactic, Antibronchospastic, and Mast Cell Stabilizing Activities
Catto, Alberto,Motta, Gianni,Tajana, Alberto,Cazzulani, Pietro,Nardi, Dante,Leonardi, Amedeo
, p. 13 - 19 (2007/10/02)
New 1-(2-pyridinyl)piperazine derivatives were synthesized and tested as inhibitors of the reaginic passive cutaneous anaphylaxis in the rat (PCA), of the histamine-induced bronchospasm in the guinea pig, and of the rat mesenteric mast cell degranulation induced by compound 48/80.On the basis of test results, a series of N-(substituted phenyl)-ω-alkanamides were prepared.The nature of substituents at the anilide ring strongly influenced mast cell stabilizing activity, whereas it was less determining in the case of the other two tests.No clear correlation between the most common physicochemical parameters (?, ?, Vw volume) of substituents and activity could be detected.With regard to the position of substituents at the anilide ring, the rank order of potency, in the PCA and bronchoconstriction tests, was para > meta > ortho.Introduction of substituents in the 1-(2-pyridinyl)piperazinyl moiety of the N-(substituted phenyl)propanamide derivatives hardly affected activity, or the effect was deleterious.Some of the new compounds exhibited a simultaneous remarkable activity in all the three assays employed.
