104373-97-9Relevant academic research and scientific papers
Synthesis of 4-Trifluoromethylated 1,3-Butadienes via Palladium Catalyzed Heck Reaction
Li, Yang,Hao, Meng,Chang, Yu-Chen,Liu, Yuan,Wang, Wen-Fei,Sun, Ning,Zhu, Wen-Qing,Gao, Ziwei
supporting information, p. 2962 - 2966 (2021/08/23)
1,3-Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs. A new and effective method for the synthesis of 4-trifluoromethylated 1,3-butadiene through the fluorinated Heck reaction catalyzed by Pd(0) is described. Without additives, 1-chloro-3,3,3-trifluoropropene (an inexpensive CF3 structural unit that is harmless to ozone) reacts with enamide to synthesize 4-trifluoromethylated 1,3-butadienes with good yield, high regioselectivity and chemical selectivity, and strong tolerance of substrate functional groups such as alkynes, aldehyde, and ester groups.
1-(2-Pyridinyl)piperazine Derivatives with Antianaphylactic, Antibronchospastic, and Mast Cell Stabilizing Activities
Catto, Alberto,Motta, Gianni,Tajana, Alberto,Cazzulani, Pietro,Nardi, Dante,Leonardi, Amedeo
, p. 13 - 19 (2007/10/02)
New 1-(2-pyridinyl)piperazine derivatives were synthesized and tested as inhibitors of the reaginic passive cutaneous anaphylaxis in the rat (PCA), of the histamine-induced bronchospasm in the guinea pig, and of the rat mesenteric mast cell degranulation induced by compound 48/80.On the basis of test results, a series of N-(substituted phenyl)-ω-alkanamides were prepared.The nature of substituents at the anilide ring strongly influenced mast cell stabilizing activity, whereas it was less determining in the case of the other two tests.No clear correlation between the most common physicochemical parameters (?, ?, Vw volume) of substituents and activity could be detected.With regard to the position of substituents at the anilide ring, the rank order of potency, in the PCA and bronchoconstriction tests, was para > meta > ortho.Introduction of substituents in the 1-(2-pyridinyl)piperazinyl moiety of the N-(substituted phenyl)propanamide derivatives hardly affected activity, or the effect was deleterious.Some of the new compounds exhibited a simultaneous remarkable activity in all the three assays employed.
Synthesis of Benzoquinolizine Derivatives
Merchant, J. R.,Pathare, P. M.
, p. 471 - 472 (2007/10/02)
The reaction of α,β-unsaturated acids with aromatic amines in the presence of PPA affords directly benzo-quinolizines (I).The structures of all the compounds have been established on the basis of elemental analyses and spectral data.
