104384-61-4

Upstream product

• 636-41-9 2-methyl-1H-pyrrole 
• 577-19-5 2-nitrophenyl bromide 
• 552-89-6 2-nitro-benzaldehyde 
• 14674-35-2 N-(2-nitrobenzylidene)-p-toluenesulfonamide 
• 1296868-36-4 2-methyl-1-[(4-methylphenyl)sulfonyl]-5-(2-nitrophenyl)-1H-pyrrole 
• 37638-28-1 ethyl 5-methyl-2-(2-nitrophenyl)-pyrrole-4-carboxylate 
• 104384-60-3 2-methyl-5-(2-nitrophenyl)-1H-pyrrole-3-carboxylic acid 

Relevant academic research and scientific papers

Chiral Phosphoric Acid-Catalyzed Pictet-Spengler Reactions for Synthesis of 5′,11′-Dihydrospiro[indoline-3,6′-indolo[3,2-c]qui-nolin]-2-ones Containing Quaternary Stereocenters

Chiral phosphoric acid-catalyzed Pictet-Spengler reactions of 2-(1H-indolyl)aniline derivatives and isatins by the condensation/cyclization process have been realized. A series of enantioenriched 5′,11′-dihydrospiro[indoline-3,6′-indolo[3,2-c]quinolin]-2-ones bearing quaternary stereogenic centers were obtained with excellent yields and up to >99% ee. This protocol was suitable for the Pictet-Spengler reactions of 2-(1-benzyl-5-methyl-1H-pyrrol-2-yl)aniline, and a variety of 1′,5′-dihydro-spiro[indoline-3,4′-pyrrolo[3,2-c]quinolin]-2-ones could also be obtained in good yields and up to 88% ee.

One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(iii) catalysis is reported.

POLYCONDENSED NITROGEN HETEROCYCLES. PART 18. INFLUENCE OF pH IN THE INTRAMOLECULAR COUPLING REACTION OF DIAZOTIZED 2-(2-AMINOPHENYL)-PYRROLES

1H-pyrrolocinnolines (3) or pyrrolobenzotriazines (4) are obtained for amines (1) depending on the pH of the medium.The reaction course was explained on the basis of the position of the equilibrium 2 2' affected by the substituents.