104406-47-5

Upstream product

• 20790-73-2 (2S,3R)-3-hydroxyaspartic acid β-methyl ester 
• 501-53-1 benzyl chloroformate 
• 20790-73-2 α-Methyl L-erythro-β-Hydroxyaspartate Hydrochloride 

Downstream Products

• 97764-69-7 (2S,3R)-2-<(benzyloxycarbonyl)amino>-4-(chloroacetoxy)-3-(mesyloxy)butanamide 
• 92973-23-4 (2S,3R)-2-<(benzyloxycarbonyl)amino>-4-(chloroacetoxy)-3-hydroxybutanamide 
• 92754-76-2 (2S,3R)-2-<(benzyloxycarbonyl)amino>-3,4-dihydroxybutanamide 
• 92973-33-6 tetrabutylammonium (3S,4S)-3-<(benzyloxycarbonyl)amino>-4-(hydroxymethyl)-2-oxoazetidine-1-sulfonate 
• 92754-75-1 (2S,3R)-2-<(benzyloxycarbonyl)amino>-3-hydroxy-4-butanolide 

Relevant academic research and scientific papers

Dehydrooligopeptides. X. Useful Synthetic Method for (E)- and (Z)-Isomers of Dehydroaspartic Acids, and Their Δ1,2-Dehydrodipeptides by the Base-Catalyzed β-Elimination

Various kinds of N-benzyloxycarbonyl (E)- and (Z)-dehydroaspartic acid (Cbz-ΔAsp) derivatives were succesfully synthesized by both a base-catalyzed β-elimination of β-hydroxyaspartic acid esters (HyAsp) via their β-mesyloxy Asp derivatives and several modes of the cleavages of α-(N-Cbz)-aminomaleic acid anhydride.Moreover, for high-yield synthesis of Δ1,2-dehydrodipeptides (DHP) containing a ΔAsp residue, a similar β-elimination was applied to Δ1-DHP with C-terminal HyAsp residue.The configuration of all the new ΔAsp derivatives and their Δ1,2-DHPs were confirmed mainly on the basis of 1H NMR spectral data.