Bulletin of the Chemical Society of Japan p. 3265 - 3272 (1988)
Update date:2022-08-04
Topics:
Shin, Chung-gi
Obara, Takumi
Morita, Shigeru
Yonezawa, Yasuchika
Various kinds of N-benzyloxycarbonyl (E)- and (Z)-dehydroaspartic acid (Cbz-ΔAsp) derivatives were succesfully synthesized by both a base-catalyzed β-elimination of β-hydroxyaspartic acid esters (HyAsp) via their β-mesyloxy Asp derivatives and several modes of the cleavages of α-(N-Cbz)-aminomaleic acid anhydride.Moreover, for high-yield synthesis of Δ1,2-dehydrodipeptides (DHP) containing a ΔAsp residue, a similar β-elimination was applied to Δ1-DHP with C-terminal HyAsp residue.The configuration of all the new ΔAsp derivatives and their Δ1,2-DHPs were confirmed mainly on the basis of 1H NMR spectral data.
View MoreCompro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Refine Chemicals Science & Technology Technology Developing Co., Ltd.
Contact:+86-22-87899130
Address:No.12,west keyan road,Tianjin City
Shanghai Balmxy Pharmaceutical Co., Ltd
Contact:0086-21-24206007
Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
shanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Contact:0086-29-89196322
Address:North of the Fifth Keji Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
Doi:10.1007/BF00574329
(1984)Doi:10.1016/S0040-4020(01)82336-X
(1985)Doi:10.1139/v54-094
(1954)Doi:10.1016/j.tetlet.2008.05.070
(2008)Doi:10.1016/S0040-4039(00)88933-9
(1985)Doi:10.1016/j.tet.2005.05.090
(2005)