10441-53-9

Usage

Type of drug

Nonsteroidal anti-inflammatory drug (NSAID)

Uses

Relief of pain, fever, and inflammation

Active enantiomer

(S)-enantiomer

Inactive enantiomer

(R)-enantiomer

Mechanism of action

Inhibition of cyclooxygenase, an enzyme involved in the production of prostaglandins responsible for pain and inflammation

Commonly prescribed for

Rheumatoid arthritis, gout, and dysmenorrhea

Precautions

Use with caution and under medical supervision due to potential adverse effects on the gastrointestinal, cardiovascular, and renal systems.

Upstream product

• 14233-73-9 3-(2-hydroxynaphthalen-1-yl)propanenitrile 
• 5690-03-9 splitomicin 
• 14233-72-8 3-(naphthalen-2-yloxy)propanenitrile 
• 135-19-3 β-naphthol 
• 80515-80-6 2,2-diethoxy-5,6-benzochroman 
• 4352-89-0 3H-benzo[f]chromen-3-one 
• 80515-84-0 ethyl 3-(2-hydroxynaphthalen-1-yl)propanoate 

Downstream Products

• 1417620-51-9 3-(2-phenylnaphthalen-1-yl)propanoic acid 
• 1417620-52-0 ethyl 3-(2-phenylnaphthalen-1-yl)propanoate 
• 1417620-59-7 4-(4-fluorophenyl)-1H-phenalen-1-one 
• 1426148-36-8 4-(4-fluorophenyl)-2,3-dihydro-1H-phenalen-1-one 
• 159853-33-5 4-(4-methoxyphenyl)-1H-phenalen-1-one 
• 1426148-37-9 4-(4-methoxyphenyl)-2,3-dihydro-1H-phenalen-1-one 
• 1417620-55-3 3-(2-(4-fluorophenyl)naphthalen-1-yl)propanoic acid 
• 1426148-41-5 C₂₁H₁₉FO₂ 
• 1417620-54-2 3-(2-(4-methoxyphenyl)naphthalen-1-yl)propanoic acid 
• 1426148-42-6 C₂₂H₂₂O₃ 
• 1194808-10-0 4-phenyl-1H-phenalen-1-one 
• 1417620-50-8 4-phenyl-2,3-dihydro-1H-phenalen-1-one 
• 5690-03-9 splitomicin 

Relevant academic research and scientific papers

Inhibitors of Sir2: Evaluation of Splitomicin Analogues

Splitomicin (1) and 41 analogues were prepared and evaluated in cell-based Sir2 inhibition and toxicity assays and an in vitro Sir2 inhibition assay. Lactone ring or naphthalene (positions 7-9) substituents decrease activity, but other naphthalene substitutions (positions 5 and 6) are well-tolerated. The hydrolytically unstable aromatic lactone is important for activity. Lactone hydrolysis rates were used as a measure of reactivity; hydrolysis rates correlate with inhibitory activity. The most potent Sir2 inhibitors were structurally similar to and had hydrolysis rates similar to 1.

Chiral Hypervalent Organoiodine-Catalyzed Enantioselective Oxidative Spirolactonization of Naphthol Derivatives

Highly enantioselective oxidative dearomatization of 2-naphthol derivatives was achieved for the first time by using conformationally flexible organoiodine catalysts derived from 2-aminoalcohol as a chiral source. Moreover, with the use of these catalysts

IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT

An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. [Solution] A hypervalent iodine compound precursor (iodoarene derivative) w

Improved synthesis of 4-phenylphenalenones: The case of isoanigorufone and structural analogs

2-Hydroxy-4-phenyl-1H-phenalen-1-one (isoanigorufone, 1), a phytoalexin exclusive of Musaceae, was synthesized starting from 3-(2-hydroxynaphthalen-1- yl)propanenitrile in nine steps in an overall yield of 10%. Hydrolysis of ethyl 3-(2-phenylnaphthalen-1-

A Facile Synthesis of Dihydronaphthopyrans

Efficient and specific syntheses of naturally occurring linear dihydronaphthopyran (6a) and its angular analogues (3b and 4), from appropriate ortho-methoxynaphthaldehydes, have been described.

A facile synthesis of dihydronaphthopyrans

Efficient syntheses of the naturally occurring linear dihydronaphthopyran (6a) and its angular analogues (3b and 4), from the appropriate ortho-methoxynaphthaldehydes, are described.

New Syntheses of Coumarins

New, versatile coumarin syntheses have been developed which are based on the Claisen rearrangement of allylic or propargylic aryl ethers in which the allylic or propargylic α-carbon is further oxygenated.One proceeds by first ester exchange to the aryl dialkyl orthoacrylate which then thermally rearranges.Hydrolytic treatment gives the o-hydroxydihydrocinnamic acid from which the coumarin is obtained by ring closure and dehydrogenation.In parallel fashion, an orthopropiolate may be used, eliminating the dehydrogenation step.These processes have the adventage ofavoiding the drastic acid conditions and orientation limitations of previous coumarin syntheses.They have been applied to syntheses in good yields of coumarins obtainable by previous methods in very poor yield or not at all.