10441-53-9

Basic information

• Product Name: 2-(2-Naphthyl)-2-hydroxypropanoic acid
• Synonyms: 2-(2-Naphthyl)-2-hydroxypropanoic acid
• CAS NO: 10441-53-9
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.24
• Mol File: 10441-53-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-Naphthyl)-2-hydroxypropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Naphthyl)-2-hydroxypropanoic acid(10441-53-9)
• EPA Substance Registry System: 2-(2-Naphthyl)-2-hydroxypropanoic acid(10441-53-9)

Safety Data

• Hazardous Substances Data: 10441-53-9(Hazardous Substances Data)

Usage

Type of drug

Nonsteroidal anti-inflammatory drug (NSAID)

Uses

Relief of pain, fever, and inflammation

Active enantiomer

(S)-enantiomer

Inactive enantiomer

(R)-enantiomer

Mechanism of action

Inhibition of cyclooxygenase, an enzyme involved in the production of prostaglandins responsible for pain and inflammation

Commonly prescribed for

Rheumatoid arthritis, gout, and dysmenorrhea

Precautions

Use with caution and under medical supervision due to potential adverse effects on the gastrointestinal, cardiovascular, and renal systems.

Upstream product

• 4352-89-0 3H-benzo[f]chromen-3-one 
• 135-19-3 β-naphthol 
• 14233-72-8 3-(naphthalen-2-yloxy)propanenitrile 
• 80515-80-6 2,2-diethoxy-5,6-benzochroman 
• 5690-03-9 splitomicin 
• 80515-84-0 ethyl 3-(2-hydroxynaphthalen-1-yl)propanoate 
• 14233-73-9 3-(2-hydroxynaphthalen-1-yl)propanenitrile 

Downstream Products

• 5690-03-9 splitomicin 
• 1417620-51-9 3-(2-phenylnaphthalen-1-yl)propanoic acid 
• 1417620-52-0 ethyl 3-(2-phenylnaphthalen-1-yl)propanoate 
• 1417620-59-7 4-(4-fluorophenyl)-1H-phenalen-1-one 
• 1426148-36-8 4-(4-fluorophenyl)-2,3-dihydro-1H-phenalen-1-one 
• 159853-33-5 4-(4-methoxyphenyl)-1H-phenalen-1-one 
• 1426148-37-9 4-(4-methoxyphenyl)-2,3-dihydro-1H-phenalen-1-one 
• 1417620-55-3 3-(2-(4-fluorophenyl)naphthalen-1-yl)propanoic acid 
• 1426148-41-5 C₂₁H₁₉FO₂ 
• 1417620-54-2 3-(2-(4-methoxyphenyl)naphthalen-1-yl)propanoic acid 
• 1426148-42-6 C₂₂H₂₂O₃ 
• 1194808-10-0 4-phenyl-1H-phenalen-1-one 
• 1417620-50-8 4-phenyl-2,3-dihydro-1H-phenalen-1-one 

Relevant articles and documents

Inhibitors of Sir2: Evaluation of Splitomicin Analogues

Splitomicin (1) and 41 analogues were prepared and evaluated in cell-based Sir2 inhibition and toxicity assays and an in vitro Sir2 inhibition assay. Lactone ring or naphthalene (positions 7-9) substituents decrease activity, but other naphthalene substitutions (positions 5 and 6) are well-tolerated. The hydrolytically unstable aromatic lactone is important for activity. Lactone hydrolysis rates were used as a measure of reactivity; hydrolysis rates correlate with inhibitory activity. The most potent Sir2 inhibitors were structurally similar to and had hydrolysis rates similar to 1.

-

-

IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT

An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. [Solution] A hypervalent iodine compound precursor (iodoarene derivative) w

A Facile Synthesis of Dihydronaphthopyrans

Efficient and specific syntheses of naturally occurring linear dihydronaphthopyran (6a) and its angular analogues (3b and 4), from appropriate ortho-methoxynaphthaldehydes, have been described.