14233-73-9

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(2-hydroxy-1-naphthyl)propanenitrile is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure and reactivity make it a valuable component in the creation of various organic compounds with potential medicinal properties.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(2-hydroxy-1-naphthyl)propanenitrile is employed as a building block for the preparation of a wide array of functional materials and organic compounds. Its distinctive chemical features contribute to the development of new molecules with specific applications.
Used in Medicinal Chemistry Research:
Due to its potential biological activities, 3-(2-hydroxy-1-naphthyl)propanenitrile is also of interest in medicinal chemistry. Researchers explore its properties to understand its interactions with biological systems, which may lead to the discovery of new therapeutic agents or probes for biological studies.
Used in Chemical Industry:
3-(2-hydroxy-1-naphthyl)propanenitrile finds applications across various sectors of the chemical industry, where it is leveraged for the production of specialty chemicals, dyes, and other related products that benefit from its specific chemical characteristics.

InChI:InChI=1/C13H11NO/c14-9-3-6-12-11-5-2-1-4-10(11)7-8-13(12)15/h1-2,4-5,7-8,15H,3,6H2

Upstream product

• 135-19-3 β-naphthol 
• 14233-72-8 3-(naphthalen-2-yloxy)propanenitrile 
• 76466-82-5 7-cyano-2,3-benzobicyclo<4.2.0>octa-2,4-dien-6-ol trimethylsilyl ether 
• 76466-81-4 endo-4-cyanotricyclo<6.4.0.0^2,5>dodeca-1(12),6,8,10-tetraen-5-ol 
• 107-13-1 acrylonitrile 
• 56-23-5 tetrachloromethane 
• 71-43-2 benzene 

Downstream Products

• 10441-53-9 3-(2-hydroxynaphthalen-1-yl)propanoic acid 
• 5690-03-9 splitomicin 
• 1417620-51-9 3-(2-phenylnaphthalen-1-yl)propanoic acid 
• 1417620-52-0 ethyl 3-(2-phenylnaphthalen-1-yl)propanoate 
• 1417620-59-7 4-(4-fluorophenyl)-1H-phenalen-1-one 
• 1426148-36-8 4-(4-fluorophenyl)-2,3-dihydro-1H-phenalen-1-one 
• 159853-33-5 4-(4-methoxyphenyl)-1H-phenalen-1-one 
• 1426148-37-9 4-(4-methoxyphenyl)-2,3-dihydro-1H-phenalen-1-one 
• 1417620-55-3 3-(2-(4-fluorophenyl)naphthalen-1-yl)propanoic acid 
• 1426148-41-5 C₂₁H₁₉FO₂ 
• 1417620-54-2 3-(2-(4-methoxyphenyl)naphthalen-1-yl)propanoic acid 
• 1426148-42-6 C₂₂H₂₂O₃ 
• 1194808-10-0 4-phenyl-1H-phenalen-1-one 
• 1417620-50-8 4-phenyl-2,3-dihydro-1H-phenalen-1-one 

Relevant academic research and scientific papers

Photoadditions of 1- and 2-Naphthols and Derivatives to Acrylonitrile. Conversion of the Cyclobutane Adducts to Cyanoethylnaphthols

The photoreactions of 1- and 2-naphthol, their trimethylsilyl (Me3Si) ethers, and 1-methoxynaphthalene with acrylonitrile in a 1:1 isopropyl alcohol-tert-butyl alcohol mixture have been investigated.Irradiation of 2-naphthol and acrylonitrile gives 7-cyano-2,3-benzobicycloocta-2,4-dien-6-ol (3) while 2-naphthol trimethylsilyl ether gives the trimethylsilyl ether of 3.Base treatment of 3 or 3 trimethylsilyl ether gave 1-(2-cyanoethyl)-2-naphthol.Photoaddition of 1-naphthol trimehylsilyl ether and acrylonitrile gives8-cyano-2,3-benzobicycloocta-2,4-dien-1-ol trimethylsilyl ether, which is converted to the parent alcohol (6) by acid or to 2-(2-cyanoethyl)-1-naphthol (7) by base.The latter was also isolated in poor yield from the photolysis of 1-naphthol and acrylonitrile.Photoaddition of 1-methoxynaphthalene and acrylonitrile affords 1-methoxy-8-cyano-2,3-benzobicycloocta-2,4-diene (8) and endo-4-methoxy-7-cyano-2,3-benzobicycloocta-2,4-diene (9), in the ratio 1:1. 2,6-Dimethoxynaphthalene adds to acrylonitrile, giving the 7-cyano-6-methoxy-2,3-(2'-methoxy)benzobicycloocta-2,4-diene (16).These photoadditions are of possible synthetic utility for the ortho cyanoethylation of phenols.

Radical scavenging capacity of 2,4-dihydroxy-9-phenyl-1 H -phenalen-1-one: A functional group exclusion approach

2,4-Dihydroxy-9-phenyl-1H-phenalen-1-one (4-hydroxyanigorufone, 1), a compound isolated from Anigozanthos flavidus and Monochoria elata, displayed a high radical scavenging capacity in the ORAC assay. A systematic approach was adopted in order to explore

Synthesis of musafluorone: A naphthoxanthenone isolated from Musa acuminata

5-Methoxy-3H-naphtho[2,1,8-mna]xanthen-3-one (musafluorone, 1), the only naphthoxanthenone reported so far from Musaceae, was synthesized starting from 2-naphthol in nine steps and resulted in an overall yield of 3%. Grignard addition of phenylmagnesium b