5690-03-9 Usage
Uses
Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent.
Definition
ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027
General Description
A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
Biological Activity
Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 5690-03-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,9 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5690-03:
(6*5)+(5*6)+(4*9)+(3*0)+(2*0)+(1*3)=99
99 % 10 = 9
So 5690-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
5690-03-9Relevant articles and documents
Organocatalyst-Mediated Dynamic Kinetic Enantioselective Acylation of 2-Chromanols
Glazier, Daniel A.,Schroeder, John M.,Liu, Jitian,Tang, Weiping
supporting information, p. 4646 - 4649 (2018/11/10)
We recently developed a novel chiral catalyst-directed dynamic kinetic diastereoselective acylation of hemiacetals for the synthesis of carbohydrates. In this update, we describe a catalytic method for the dynamic kinetic enantioselective acylation of 2-c
IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT
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Paragraph 0106, (2014/01/23)
An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. [Solution] A hypervalent iodine compound precursor (iodoarene derivative) w
Anionic alternating copolymerization of epoxide and six-membered lactone bearing naphthyl moiety
Sudo, Atsushi,Zhang, Yuan,Endo, Takeshi
experimental part, p. 619 - 624 (2012/01/13)
This article describes the anionic copolymerization of glycidyl phenyl ether (GPE) and 1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one (DHNP), a six-membered aromatic lactone bearing naphthyl moiety. The copolymerization proceeded in a 1:1 alternating manner, to
