10442-84-9

Upstream product

• 10442-83-8 2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethanol 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 349-03-1 1-bromo-4-trifluoromethyl-2-nitrobenzene 

Downstream Products

• 911381-06-1 ethyl 3-(4-{2-[2,5-bis(trifluoromethyl)-1H-benzimidazol-1-yl]ethoxy}phenyl)-2-ethoxypropanoate 

Relevant academic research and scientific papers

Regulating Cofactor Balance In Vivo with a Synthetic Flavin Analogue

A novel strategy to regulate cofactor balance in vivo for whole-cell biotransformation using a synthetic flavin analogue is reported. High efficiency, easy operation, and good applicability were observed for this system. Confocal laser scanning microscopy was employed to verify that the synthetic flavin analogue can directly permeate into Escherichia coli cells without modifying the cell membrane. This work provides a promising intracellular redox regulatory approach to construct more efficient cell factories.

Combining Flavin Photocatalysis and Organocatalysis: Metal-Free Aerobic Oxidation of Unactivated Benzylic Substrates

We report a system with ethylene-bridged flavinium salt 2b which catalyzes the aerobic oxidation of toluenes and benzyl alcohols with high oxidation potential (Eox > +2.5 V vs SCE) to give the corresponding benzoic acids under visible light irradiation. This is caused by the high oxidizing power of excited 2b (E(2b?) = +2.67 V vs SCE) involved in photooxidation and by the accompanying dark organocatalytic oxygenation provided by the in situ formed flavin hydroperoxide 2b-OOH.

CHEMICAL REGENERATION METHOD OF OXIDIZED COENZYME NAD (P)+

It discloses a chemical regeneration method of oxidized coenzyme NAD(P)+ which is under an oxygen or air atmosphere condition, adding a catalytic amount of bridged flavin, and oxidizing NAD(P)H to obtain NAD(P)+. The catalyst for regeneration of cofactor is cheap and easily available small organic molecule having no noble metal; this regeneration system can regenerate NADH and NADPH; this regeneration system has a wide pH range and temperature range, being applicable to various oxidation reactions catalyzed by nicotinamide-dependent oxidoreductase.

SUBSTITUTED CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES AND LIPID DISORDERS, THEIR PREPARATION AND USE

The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1 ; or pharmaceutically acceptable salts thereof. The present invention also includes pharmaceutical c

N1,N10-Ethylene-bridged high-potential flavins: Synthesis, characterization, and reactivity

N1,N10-Ethyleneisoalloxazinium chloride and its 8-Cl-, 7-CF3-, and 3-CH3-7-CF3-substituted analogs were synthesized for the purpose of exhibiting thermal reactivity with organic substrates. The new flavins were characterized spectroscopically and electrochemically, and were found to react with amines, thiols, and phenylhydrazine, the latter case exhibiting catalytic aerobic recycling. Reactions of aliphatic benzylic and cyclopropyl amines with the 7-CF3 analog were also compared to their oxidations by tris(phenanthroline)iron(III). All reactions of the flavinium salts appear to occur through heterolytic rather than homolytic mechanisms.

Pyrrolyl quinoxalindiones their production and use as AMPA receptor antagonists

Pyrrolylquinoxalinediones of the formula I and their tautomeric and isomeric forms, and their physiologically tolerated salts are described, where the variables have the following meaning: R1hydrogen, C1-C6-alkyl, substitu

Quinoxalines and drugs prepared therefrom

Quinoxaline-2,3-(1H,4H)-diones of the formula I STR1 and their tautomeric and enantiomeric forms and their physiologically tolerated salts, the variables R, R 1 and R 2 have the meanings specified in claim 1, and are useful for therapeutic treatment of neurodegenerative disorders, neurotoxic disturbances or as antiepileptics, antidepressants and anxiolytics; and drugs composed thereof.