1044277-06-6Relevant articles and documents
Synthesis of 4-arylcoumarins via palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamates with diaryliodonium salts
Yang, Yang,Han, Jianwei,Wu, Xunshen,Xu, Shujia,Wang, Limin
supporting information, p. 3809 - 3812 (2015/06/08)
The palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamate ester derivatives by using diaryliodonium(III) salts has been developed. With this method, 4-arylcoumarins were easily prepared in good to excellent yields under base-free conditions
Convergent, fit-for-purpose, kilogram-scale synthesis of a 5-lipoxygenase inhibitor
Ouellet, Stephane G.,Gauvreau, Danny,Cameron, Mark,Dolman, Sarah,Campeau, Louis-Charles,Hughes, Gregory,O'Shea, Paul D.,Davies, Ian W.
, p. 214 - 219 (2012/06/05)
Process research and development of a synthetic route towards a novel 5-lipoxygenase inhibitor is described. The synthetic route provided 1 in 27% yield in nine steps (seven steps in the longest linear sequence) and was performed on kilogram scale. The synthesis began with the preparation of the coumarin core via an efficient von Pechmann condensation. The triazole fragment was obtained via a regioselective copper-catalyzed [3 + 2] cycloaddition between a chiral alkyne and the coumarin azide.
Novel pharmaceutical compounds
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Page/Page column 20, (2008/12/07)
The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.