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4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one is a flavonoid compound, a subclass of natural compounds found in various plants. It is a derivative of 2H-chromen-2-one, also known as coumarin, and is distinguished by the presence of a fluorophenyl group at the 3 position and a methyl group at the 7 position of the chromenone ring. 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one possesses potential biological activities such as antioxidant, anti-inflammatory, and anticancer properties, making it a promising candidate for pharmaceutical and medical research.

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  • 1044277-06-6 Structure
  • Basic information

    1. Product Name: 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one
    2. Synonyms: 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one;2H-1-Benzopyran-2-one, 4-(3-fluorophenyl)-7-methyl-
    3. CAS NO:1044277-06-6
    4. Molecular Formula: C16H11FO2
    5. Molecular Weight: 254.2557432
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1044277-06-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.272
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one(1044277-06-6)
    11. EPA Substance Registry System: 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one(1044277-06-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1044277-06-6(Hazardous Substances Data)

1044277-06-6 Usage

Uses

Used in Pharmaceutical Industry:
4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one is used as a pharmaceutical candidate for its potential antioxidant, anti-inflammatory, and anticancer properties. Its unique chemical structure and biological activities make it a promising candidate for the development of new drugs and therapies.
Used in Medical Research:
In the field of medical research, 4-(3-fluorophenyl)-7-methyl-2H-chromen-2-one is utilized for studying its potential biological activities and exploring its efficacy in treating various diseases and conditions, particularly those related to oxidative stress, inflammation, and cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 1044277-06-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,4,2,7 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1044277-06:
(9*1)+(8*0)+(7*4)+(6*4)+(5*2)+(4*7)+(3*7)+(2*0)+(1*6)=126
126 % 10 = 6
So 1044277-06-6 is a valid CAS Registry Number.

1044277-06-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(3-fluorophenyl)-7-methylchromen-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1044277-06-6 SDS

1044277-06-6Relevant articles and documents

Synthesis of 4-arylcoumarins via palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamates with diaryliodonium salts

Yang, Yang,Han, Jianwei,Wu, Xunshen,Xu, Shujia,Wang, Limin

supporting information, p. 3809 - 3812 (2015/06/08)

The palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamate ester derivatives by using diaryliodonium(III) salts has been developed. With this method, 4-arylcoumarins were easily prepared in good to excellent yields under base-free conditions

Convergent, fit-for-purpose, kilogram-scale synthesis of a 5-lipoxygenase inhibitor

Ouellet, Stephane G.,Gauvreau, Danny,Cameron, Mark,Dolman, Sarah,Campeau, Louis-Charles,Hughes, Gregory,O'Shea, Paul D.,Davies, Ian W.

, p. 214 - 219 (2012/06/05)

Process research and development of a synthetic route towards a novel 5-lipoxygenase inhibitor is described. The synthetic route provided 1 in 27% yield in nine steps (seven steps in the longest linear sequence) and was performed on kilogram scale. The synthesis began with the preparation of the coumarin core via an efficient von Pechmann condensation. The triazole fragment was obtained via a regioselective copper-catalyzed [3 + 2] cycloaddition between a chiral alkyne and the coumarin azide.

Novel pharmaceutical compounds

-

Page/Page column 20, (2008/12/07)

The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

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