1044743-77-2Relevant academic research and scientific papers
Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction
Elders, Niels,Ruijter, Eelco,De Kanter, Frans J. J.,Groen, Marinus B.,Orru, Romano V. A.
experimental part, p. 4961 - 4973 (2009/04/21)
Selective formation of 2H-2-imidazolines and 2-substituted oxazoles by using a multicomponent reaction of amines, either aldehydes or ketones, and a-acidic isocyano amides or esters is described. By selecting the appropriate solvent, AgI or CuI catalyst, or by employing a weak Bronsted acid, the product formation can be fully controlled and directed quantitatively to the desired heterocyclic scaffold. The described experimental procedures not only significantly increase the scope of compatible inputs for this complexitygenerating three-component reaction, but also allow for considerable chemical diversity: At least four diversity points in two distinct scaffolds can be exploited in this way.
