853945-70-7

Upstream product

• 1197-58-6 1-(isocyanomethyl)-4-methoxybenzene 
• 616-38-6 carbonic acid dimethyl ester 
• 2393-23-9 4-methoxy-benzylamine 
• 13226-99-8 amino(3-chloro-4-methoxyphenyl)acetic acid methyl ester hydrochloride 
• 143323-39-1 N-formyl-4-methoxyphenylglycine methyl ester 

Downstream Products

• 1039024-85-5 (2R,3R)-methyl 3-(4-bromophenyl)-2-(4-methoxyphenyl)-4-nitro-2,3-dihydro-1H-pyrrole-2-carboxylate 
• 1044743-61-4 methyl 1-benzyl-4-(4-methoxyphenyl)-5,5-dimethyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1044743-77-2 C₂₁H₂₄N₂O₃ 

Relevant academic research and scientific papers

Catalytic enantioselective Michael addition of α-aryl-α- isocyanoacetates to vinyl selenone: Synthesis of α,α-disubstituted α-amino acids and (+)- and (-)-trigonoliimine A

Be like Mike: The title reaction in the presence of the catalyst 1 afforded Michael adducts in excellent yields and enantioselectivities. The adducts were readily converted into α,α′-disubstituted α-amino acids. The enantioselective total synthesis of bot

Mild oxidative one-carbon homologation of aldehyde to amide

One-carbon homologation of aldehyde into amide is realized in one-pot by its reaction with potassium α-p-methoxyphenyl-α-isocyano acetic acid (1c) and hydrochloride salt of dimethylamine (3a) in toluene at room temperature followed by acidic workup. In this multicomponent reaction, 1c served as donor of the CONH2 function to aldehyde, while the dimethylamine acted as a shuttle molecule to initiate/terminate the sequence and to mediate the internal redox process of one of the three-component adducts. Ready accessibility, nominal cost of the reagents, and mild conditions are attractive features of the present method. Copyright