104483-03-6

Basic information

• Product Name: Benzeneacetic acid, -alpha--hydroxy-4-(2-methylpropyl)- (9CI)
• Synonyms: Benzeneacetic acid, -alpha--hydroxy-4-(2-methylpropyl)- (9CI)
• CAS NO: 104483-03-6
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25364
• Product Categories: PHENYL
• Mol File: 104483-03-6.mol

Chemical Properties

• Boiling Point: 363.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.148±0.06 g/cm3(Predicted)
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: Benzeneacetic acid, -alpha--hydroxy-4-(2-methylpropyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, -alpha--hydroxy-4-(2-methylpropyl)- (9CI)(104483-03-6)
• EPA Substance Registry System: Benzeneacetic acid, -alpha--hydroxy-4-(2-methylpropyl)- (9CI)(104483-03-6)

Safety Data

• Hazardous Substances Data: 104483-03-6(Hazardous Substances Data)

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 75-09-2 dichloromethane 
• 538-93-2 1-phenyl-2-methylpropane 
• 7732-18-5 water 
• 609-09-6 Diethyl ketomalonate 

Downstream Products

• 1553-60-2 ibufenac 
• 56374-25-5 4-(isobutyl)phenacyl chloride 
• 30095-48-8 2-bromo-1-(4-isobutylphenyl)-1-ethanone 

Relevant articles and documents

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

Optically pure 4-aryl-2-hydroxytetronic acids

The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aidehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, and additionally as inhibitors of cyclooxygenase and 5-lipoxygenase. The invention further relates to the pharmaceutical use of such.compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis, and in the treatment of various inflammatory pathologies, especially arthritis.

INDOLE DERIVATIVES AND THEIR USE FOR TESTOSTERONE 5-ALPHA-REDUCTASE-MEDIATED DISEASES

Indole derivatives of the formula and pharmaceutical compositions thereof. They are useful for treating or preventing testosterone 5-alpha-reductase-mediated diseases, such as alopecia, acnes and prostatism

Process for preparing α-hydroxy-alkanoic acids and compounds obtained by this process

The invention relates to a process for preparing α-hydroxy-alkanoic acids of general formula: STR1 in which R represents hydrogen or a lower alkyl radical and Cy represents phenyl or a heterocyclic radical, both radicals optionally comprising one or more substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl radicals and halogen atoms, process which comprises the treatment of an α,α-dihalogenated ketone of general formula: STR2 in which R and Cy have the same meaning as above and X represents chlorine, bromine or iodine, in the presence of an aqueous solution of an alkali metal hydroxide and a non polar organic solvent selected from an aromatic or alicyclic hydrocarbon, the treatment being carried out at a temperature between the boiling temperature of the reaction medium at atmospheric pressure and 240° C. under pressure and the alkali metal so formed is then acidified to obtain the desired acid.