104486-05-7

Usage

InChI:InChI=1/C12H15ClO2/c1-8(2)11(12(14)15-3)9-4-6-10(13)7-5-9/h4-8,11H,1-3H3

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 67-56-1 methanol 
• 2012-74-0 2-(4-chlorophenyl)-3-methylbutyric acid 
• 86618-06-6 methyl 2-(4-chlorophenyl)-3-methylbutanoate 
• 956498-38-7 α-cyano-3-phenoxybenzyl S-(+)-2-(4-chlorophenyl)isovalerate 
• 924-50-5 Methyl 3,3-dimethylacrylate 
• 106-39-8 bromochlorobenzene 
• 75-30-9 2-iodo-propane 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and Applications of Unquaternized C-Bound Boron Enolates

A general and facile method to prepare unquaternized C-bound boron enolates by a ligand-controlled O-to-C isomerization is reported. Using this protocol, C-bound pinacolboron enolates have been isolated in pure form for the first time, and have been fully characterized by NMR spectroscopy and X-ray crystallography. In contrast to the general perception, such C-boron enolates are stable without coordinative saturation at the boron. Moreover, C-boron enolates present reactivities that are distinct from the O-boron enolates, and their applications in C-O and C-C bond formations are demonstrated.

(R)-ARYLKYLAMINO DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to selected (R)-arylalkylamino derivatives. These compounds show a surprising potent inhibitory effect on C5a induced human PMN chemotaxis. The compounds of the invention absolutely lack of CXCL8 inhibitory activity. Said com

Process for preparing (S)- alpha-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)-isovalerate

The present invention relates to an environmentally benign process for the preparation of (S)-α-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)isovalerate from its diastereomeric mixture (RS)-α-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl) isovalerate.

ENZYMATIC RESOLUTION OF METHYL 2-ALKYL-2-ARYLACETATES

Horse liver esterase, used as its inexpensive commercial acetone powder, catalyzes the selective hydrolysis of methy 2-alkyl-2-arylacetates to afford R(-)-2-alkyl-2-arylacetic acids and S(+)-methyl 2-alkyl-2-arylacetates.

Asymmemtric Hydrolysis of (+/-)-α-Substituted Carboxylic Acid Esters with Microorganisms

Microorganisms that hydrolyze methyl 2-phenylpropionate (1) or reduce 4-phenyl-2-butanone (3) were screened from 250 type cultures.Several Aspergilli and two bacteria hydrolyzed ester 1, and Asp. sojae IAM 2703 preferentially hydrolyzed (R)-isomer of (+/-)-1, whereas Bacillus subtilis var. niger IFO 3108 and Mycobacterium smegmatis ATCC 10143 preferentially hydrolyzed (S)-isomer.The hydrolysis of the related esters of 1 with these organisms was also examined.