10457-70-2

Basic information

• Product Name: (2Z)-3-methyl-2-phenylpent-2-enoic acid
• CAS NO: 10457-70-2
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.2384
• Mol File: 10457-70-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 296.4°C at 760 mmHg
• Flash Point: 202.1°C
• Density: 1.07g/cm³
• Vapor Pressure: 0.000647mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: (2Z)-3-methyl-2-phenylpent-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-methyl-2-phenylpent-2-enoic acid(10457-70-2)
• EPA Substance Registry System: (2Z)-3-methyl-2-phenylpent-2-enoic acid(10457-70-2)

Safety Data

• Hazardous Substances Data: 10457-70-2(Hazardous Substances Data)

Usage

Description

(2Z)-3-methyl-2-phenylpent-2-enoic acid, also known as 2Z-3-methyl-2-phenyl-2-pentenoic acid, is a carboxylic acid with a chemical formula of C11H12O2. It is a colorless, oily liquid with a slightly fruity odor and belongs to the class of organic compounds known as enoic acids.

Uses

Used in Pharmaceutical Synthesis:
(2Z)-3-methyl-2-phenylpent-2-enoic acid is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique chemical structure and properties make it a valuable component in the synthesis of medicinal compounds.
Used in Flavoring Agents:
(2Z)-3-methyl-2-phenylpent-2-enoic acid is used as a flavoring agent in food and beverages, providing a slightly fruity aroma and enhancing the overall taste experience.
Used in Medicinal Chemistry and Pharmaceutical Research:
Due to its unique chemical structure and properties, (2Z)-3-methyl-2-phenylpent-2-enoic acid has potential applications in the field of medicinal chemistry and pharmaceutical research, where it can be utilized for the development of new drugs and therapeutic agents.

Upstream product

• 103-82-2 phenylacetic acid 
• 148-19-6 3-hydroxy-3-methyl-2-phenyl-valeric acid 
• 673-32-5 1-Phenylprop-1-yne 
• 124-38-9 carbon dioxide 
• 557-20-0 diethylzinc 
• 622-76-4 1-phenyl-1-butyne 
• 544-97-8 dimethyl zinc(II) 
• 75-16-1 methylmagnesium bromide 

Relevant articles and documents

Stereospecific Electrophilic Fluorocyclization of α,β-Unsaturated Amides with Selectfluor

An efficient fluorocyclization of α,β-unsaturated amides through a formal halocyclization process is developed. The reaction proceeds under transition-metal-free conditions and leads to the formation of fluorinated oxazolidine-2,4-diones with excellent regio- and diastereoselectivity. The evaluation of the reaction mechanism based on preliminary experiments and density functional theory calculations suggests that a synergetic syn-oxo-fluorination occurs and is followed by an anti-oxo substitution reaction. The reaction opens a new window in the field of stereospecific fluorofunctionalization.

Synthesis of Trisubstituted Acrylic Acids through Nickel-Catalyzed Carbomagnesiation of Alkynes and Carbon Dioxide Fixation

A nickel-catalyzed synthesis of trisubstituted acrylic acids from alkynes, Grignard reagents, and CO2 is reported. The reaction proceeds through carbomagnesiation of the alkyne with Grignard reagent followed by carboxylation with CO2 under mild reaction conditions in short time. Various unsymmetrical alkynes were transformed into the corresponding acid products in good yields with high stereoselectivity.

Copper-Catalyzed Carboxylation of Alkenylzirconocenes with Carbon Dioxide Leading to α,β-Unsaturated Carboxylic Acids

A variety of alkenylzirconocenes were efficiently carboxylated by CO2 utilizing the (IMes)CuCl catalyst yielding the corresponding α,β-unsaturated carboxylic acids in good yields. This reaction could be carried out in a one-pot operation via sequential carbozirconation of alkynes and carboxylation using CO2 as starting materials under room temperature.