1045822-03-4Relevant academic research and scientific papers
Synthesis and Use of Trifluoromethylthiolated Ketenimines
Guérin, Thomas,Pikun, Nadiia V.,Morioka, Ryutaro,Panossian, Armen,Hanquet, Gilles,Leroux, Frédéric R.
, p. 14852 - 14855 (2020)
The synthesis of trifluoromethylthiolated ketenimines is herein described. They are easily synthesized from the corresponding α-trifluoromethylthiolated oximes upon activation with triflic anhydride and a base. The presumed nitrilium ion resulting from the Beckmann rearrangement is deprotonated to lead to the key intermediate, whose stability brought by the fluorinated substituent was unforeseeable. The reaction of these new building blocks with a variety of nucleophiles affords a vast array of cyclic and acyclic products bearing the valuable SCF3 moiety.
Palladium-Catalyzed Trifluoromethylthiolation of Chelation-Assisted C–H Bonds
Kesavan, Arunachalam,Chaitanya, Manthena,Anbarasan, Pazhamalai
supporting information, p. 3276 - 3279 (2018/07/13)
An efficient palladium-catalyzed trifluoromethylthiolation of chelation-assisted C–H bonds has been accomplished by employing a readily accessible trifluoromethylthiolating reagent. The reaction tolerates various directing groups and functional groups and allows the access to diverse trifluoromethylthiolated arenes in good yield. A plausible mechanism was proposed based on preliminary mechanistic investigations.
Synthesis of trifluoromethanesulfinamidines and -sulfanylamides
Ferry, Aurelien,Billard, Thierry,Langlois, Bernard R.,Bacque, Eric
scheme or table, p. 9362 - 9365 (2009/04/11)
(Chemical Equation Presented) Fluorinated moieties constitute important substituents used in many applications to modify the properties of molecules. The action of DAST onto Ruppert's reagent yields to a not isolable intermediate that can then react with various primary amines to give trifluoromethanesulfinamidines and trifluoromethane-sulfanylamides. Such compounds were unknown until now and constitute interesting new families of fluorinated molecules.
