104599-10-2 Usage
Description
1H-Indol-5-ol, 2-(4-hydroxyphenyl)-1-[(4-hydroxyphenyl)methyl]-3-methyl-, commonly known as Indirubin, is a chemical compound derived from indol-5-ol. It features two hydroxyphenyl groups and a methyl group attached to the indol ring, which contribute to its potential medicinal properties. Indirubin has been studied for its anti-inflammatory, anti-cancer, and neuroprotective effects, showing promise in preclinical studies. It is believed to inhibit certain enzymes and pathways involved in inflammation and cancer progression, indicating its potential in the development of new therapeutic agents for various diseases.
Uses
Used in Pharmaceutical Industry:
Indirubin is used as a potential therapeutic agent for various diseases due to its anti-inflammatory, anti-cancer, and neuroprotective effects. Its ability to inhibit enzymes and pathways involved in inflammation and cancer progression makes it a promising candidate for the development of new medications.
Used in Cancer Treatment:
Indirubin is used as an anti-cancer agent, particularly for the treatment of various types of cancer. Its inhibitory effects on enzymes and pathways involved in cancer progression make it a valuable compound in the development of new cancer therapies.
Used in Neuroprotection:
Indirubin is used for its neuroprotective effects, which may help in the treatment of neurodegenerative diseases. Its potential to protect neurons and reduce inflammation in the brain makes it a promising compound for the development of neuroprotective therapies.
Used in Inflammation Management:
Indirubin is used for its anti-inflammatory properties, which may be beneficial in the treatment of inflammatory conditions. Its ability to inhibit inflammatory pathways makes it a potential candidate for the development of new anti-inflammatory drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 104599-10-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,5,9 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 104599-10:
(8*1)+(7*0)+(6*4)+(5*5)+(4*9)+(3*9)+(2*1)+(1*0)=122
122 % 10 = 2
So 104599-10-2 is a valid CAS Registry Number.
104599-10-2Relevant articles and documents
Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles
Kelly, Patrick M.,Bright, Sandra A.,Fayne, Darren,Pollock, Jade K.,Zisterer, Daniela M.,Williams, D. Clive,Meegan, Mary J.
, p. 4075 - 4099 (2016/08/23)
Breast cancer is the second most common cancer worldwide after lung cancer with the vast majority of early stage breast cancers being hormone-dependent. One of the major therapeutic advances in the clinical treatment of breast cancer has been the introduction of selective estrogen receptor modulators (SERMs). We describe the design and synthesis of novel SERM type ligands based on the 2-arylindole scaffold to selectively target the estrogen receptor in hormone dependent breast cancers. Some of these novel compounds are designed as bisindole type structures, while others are conjugated to a cytotoxic agent based on combretastatin A4 (CA4) which is a potent inhibitor of tubulin polymerisation. The indole compounds synthesised within this project such as 31 and 86 demonstrate estrogen receptor (ER) binding and strong antiproliferative activity in the ER positive MCF-7 breast cancer cell line with IC50values of 2.71?μM and 1.86?μM respectively. These active compounds induce apoptotic activity in MCF-7 cells with minimal effects on normal peripheral blood cells. Their strong anti-cancer effect is likely mediated by the presence of two ER binding ligands for 31 and an ER binding ligand combined with a cytotoxic agent for 86.
Tethered indoles as functionalizable ligands for the estrogen receptor
Trogden, Bridget G.,Kim, Sung Hoon,Lee, Shuyi,Katzenellenbogen, John A.
, p. 485 - 488 (2011/03/20)
To create ligands for the estrogen receptor that contain pendant groups for tethering to a poly(amido)amine (PAMAM) dendrimer, we have explored a class of N-substituted 2-phenyl indoles. Attachment of tethers of different length and chemical nature to thi
