10461-91-3

Basic information

• Product Name: N-(5-chloropyridin-2-yl)-N'-phenylurea
• Synonyms: N-(5-chloropyridin-2-yl)-N'-phenylurea
• CAS NO: 10461-91-3
• Molecular Formula: C₁₂H₁₀ClN₃O
• Molecular Weight: 248
• Mol File: 10461-91-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(5-chloropyridin-2-yl)-N'-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-chloropyridin-2-yl)-N'-phenylurea(10461-91-3)
• EPA Substance Registry System: N-(5-chloropyridin-2-yl)-N'-phenylurea(10461-91-3)

Safety Data

• Hazardous Substances Data: 10461-91-3(Hazardous Substances Data)

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 103-71-9 phenyl isocyanate 
• 201230-82-2 carbon monoxide 
• 98-95-3 nitrobenzene 
• 16110-09-1 2,5 dichloropyridine 
• 64-10-8 phenyl carbamate 
• 62-53-3 aniline 
• 55-21-0 benzamide 

Relevant articles and documents

Regioselective preparation of pyridin-2-yl ureas from 2-chloropyridines catalyzed by Pd(0)

The palladium-catalyzed ureidation reaction of 2-chloropyridines can be regioselectively performed in good yield, with both aryl and aliphatic ureas, using xantphos as the ligand, Pd(OAc)2 as the source of palladium, NaOt-Bu/H2O or N

Metal-free synthesis of pyridin-2-yl ureas from 2-aminopyridinium salts

An unprecedented base promoted domino approach has been developed for the synthesis of pyridin-2-yl urea derivatives via the reaction of 2-aminopyridinium salts and arylamines. The developed strategy tolerated a wide range of functional groups and afforded pyridin-2-yl ureas in moderate to good yields. The reaction was postulated to involve tandem cyclization, intermolecular nucleophilic addition, ring opening, and demethylation.