104614-80-4Relevant articles and documents
[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES
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, (2021/02/19)
The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
Synthesis and antiinflammatory evaluation of new 2- and 3-substituted 1,2,4-triazolo[4,3-c] and [1,5-c]quinazoline derivatives
Gineinah,Nasr,Abdelal,El-Emam,Said
, p. 243 - 252 (2007/10/03)
A series of new 5-chloro-3-substituted-1,2,4-triazolo[4,3-c]quinazolines and 5-chloro-2-substituted 1,2,4-triazolo[1,5-c]quinazolines was prepared via several synthetic routes. Most of the compounds were prepared by cyclization of 2,4-dichloroquinazoline with thiosemicarbazide or acid hydrazides; other compounds were obtained from (2-chloro-4-quinazolyl)hydrazine by reaction with carboxylic acids or acid chlorides. The synthesized compounds were evaluated as antiinflammatory agents through the carrageenin-induced paw edema test. The screening data revealed that four of the tested compounds have activity ranging from more potent to equipotent to ketoprofen. Moreover, compound 16, that was found to possess pronounced antiinflammatory activity, was tested for its analgesic activity and ulcerogenic effect as well.
Synthesis and Benzodiazepine Binding Activity of a Series of Novel Triazoloquinazolin-5(6H)-ones
Francis, John E.,Cash, William D.,Barbaz, Beverly S.,Bernard, Patrick S.,Lovell, Richard A.,et al.
, p. 281 - 290 (2007/10/02)
Investigation of tricyclic heterocycles related to the 2-arylpyrazoloquinolin-3(5H)-ones, structures with high affinity for the benzodiazepine (BZ) receptor, led to the synthesis of 2-phenyl-triazoloquinazolin-5(6H)-one, a compound wi
Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
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, (2008/06/13)
[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula STR1 wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N--R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N--R3.
