104615-64-7Relevant academic research and scientific papers
Synthesis of diverse azolo[c]quinazolines by palladium(II)- catalyzed aerobic oxidative insertion of isocyanides
Vlaar, Tjostil,Bensch, Lisa,Kraakman, Jasper,Vande Velde, Christophe M. L.,Maes, Bert U. W.,Orru, Romano V. A.,Ruijter, Eelco
, p. 1205 - 1209 (2014)
We report the palladium(II)-catalyzed aerobic oxidative coupling of isocyanides with various (2-aminophenyl)azoles using air as the stoichiometric oxidant. A diverse range of medicinally valuable azolo[c]quinazolines was obtained by this new approach.
Synthesis and evaluation of adenosine antagonist activity of a series of [1,2,4]triazolo[1,5-c]quinazolines
Balo, Carmen,Lopez, Carmen,Brea, Jose Manuel,Fernandez, Franco,Caamano, Olga
, p. 372 - 375 (2008/02/02)
A series of [1,2,4]triazolo[1,5-c]quinazolines were prepared in satisfactory yields by reaction of some derivatives of 2-aminobenzohydrazide with several hydrochlorides of aromatic amidines, and their binding affinities for the recombinant human adenosine A2A and A2B receptors were determined. None of the new compounds showed noteworthy affinity for these receptors, though a very high affinity for the A2A receptor and, consequently, a high level of A2A/A2B selectivity was revealed for one of the synthesized compounds.
Synthesis of Triazoloquinazoline and Triazolo-1,4-benzodiazepine Derivatives
Gatta, Franco,Giudice, Del, Maria Rosaria,Borioni, Maria
, p. 11 - 16 (2007/10/02)
Some triazoloquinazolin-5(6H)-ones 7, the corresponding isomers triazoloquinazolin-5(6H)-ones and the 5-amino derivatives 8,9 and 11 have been synthesized starting from the acylamidrazones 5.The preparation of 5H-triazol
