1046154-83-9

Basic information

• Product Name: 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one
• Synonyms: 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one
• CAS NO: 1046154-83-9
• Molecular Weight: 334.202
• Mol File: 1046154-83-9.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one(1046154-83-9)
• EPA Substance Registry System: 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one(1046154-83-9)

Safety Data

• Hazardous Substances Data: 1046154-83-9(Hazardous Substances Data)

Upstream product

• 96-48-0 4-butanolide 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 108-29-2 5-methyl-dihydro-furan-2-one 
• 141-78-6 ethyl acetate 

Downstream Products

• 1265072-44-3 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl nicotinate 
• 1265072-06-7 5-{2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethoxy}-5-oxopentanoic acid 
• 1265072-50-1 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl furan-2-carboxylate 
• 1265072-47-6 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl thiophene-2-carboxylate 
• 1265073-24-2 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]acetaldehyde 
• 1265071-80-4 6-chloro-4-(2-chlorophenyl)-2,3-dihydrofuro[2,3-b]quinoline 
• 1265071-83-7 6-chloro-4-(2-chlorophenyl)-2,3-dihydrothieno[2,3-b]quinoline 
• 1265072-15-8 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl 2-ethoxyacetate 
• 1265072-03-4 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl octanoate 
• 1265072-18-1 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl 2-acetoxyacetate 
• 1265072-53-4 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl 2-(1,3-dioxoisoindolin-2-yl)acetate 
• 1265072-23-8 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl cyclopentanecarboxylate 
• 1265072-29-4 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl 3-cyclohexylpropanoate 
• 1265071-88-2 2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl acetate 

Relevant articles and documents

Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents

A series of 4-aryl-6-chloro-quinoline derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely the abilities to inhibit the secretion of HBV surface antigen (HBsAg), HBV e antigen (HBeAg), and replication of HBV

Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2- hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents

A series of novel 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives were synthesized and evaluated for anti-hepatitis B virus (anti-HBV) activities in vitro to explore their structure-activity relationships (SARs). Most of the

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC50 of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively).