1046480-15-2Relevant academic research and scientific papers
Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B
Matsumaru, Takanori,Sunazuka, Toshiaki,Hirose, Tomoyasu,Ishiyama, Aki,Namatame, Miyuki,Fukuda, Takashi,Tomoda, Hiroshi,Otoguro, Kazuhiko,Omura, Satoshi
, p. 7369 - 7377 (2008)
The first, concise total synthesis of (±)-tensyuic acids B, C, and E, using chemoselective formal SN2′ type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (±)-tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosoma brucei brucei strain GUTat 3.1.
