104659-75-8Relevant academic research and scientific papers
Metal- and Solvent-Free Approach to Diversely Substituted Picolinates via Domino Reaction of Cyclic Sulfamidate Imines with β,γ-Unsaturated α-Ketocarbonyls
Biswas, Soumen,Majee, Debashis,Guin, Soumitra,Samanta, Sampak
, p. 10928 - 10938 (2017)
An efficient, solvent-free, and eco-friendly domino reaction of 5/6-membered cyclic sulfamidate imines with a variety of β, γ-unsaturated α-ketocarbonyls in neat conditions under MW irradiation promoted by DABCO as a solid organobase has been developed for the rapid construction of a novel class of densely functionalized picolinates. This interesting metal-solvent-free tactic allows a wide range of useful functionalities on the aryl rings and delivers good to excellent yields of the aforesaid aza-heterocycles within short time spans (20-40 min). A biologically promising imidazo[1,2-a]pyridine was successfully synthesized through our unique procedure.
Visible-light-initiated catalyst-free oxidative cleavage of (Z)-triaryl-substituted alkenes containing pyridyl motif under ambient conditions
Chen, Hua,Fu, Haiyan,Ge, Yicen,Li, Ruixiang,Li, Shun,Li, Wenjing,Luo, Lihua,Xu, Jiaqi,Yuan, Maolin,Zheng, Xueli
supporting information, p. 3649 - 3655 (2021/06/06)
The catalyst-free oxidative cleavage of (Z)-triaryl-substituted alkenes bearing a pyridyl motif in ambient air under the irradiation of blue LEDs at room temperature has been developed. The reaction was facile and scalable, and proceeded with good functional group tolerance, affording pharmaceutically useful 2-acyl pyridines. The electron paramagnetic resonance (EPR) studies together with control experiments showed that the singlet oxygen (1O2) and superoxide anion (O2˙?) are the reactive oxidants. The1O2generation mechanism correlated well with the photophysical properties of the substrate (Z)-triaryl-substituted alkenes, the excited state of which was proved to serve as the triplet sensitizer for the generation of1O2
Some Novel Reactions of Pyridinium-2-carboxylate Betaines
Katritzky, Alan R.,Cozens, Andrew J.,Ossana, Andrea,Rubio, Olga,Dabbas, Nadira
, p. 2167 - 2172 (2007/10/02)
Appropriate 2-ethoxycarbonylpyridinium salts are hydrolysed to 1-aryl-4,6-diphenylpyridinium-2-carboxylate betaines which undergo thermal decarboxylation to afford, in the presence of acids, 1-aryl-2,4-diphenylpyridinium salts.The intermediate ylides are
