104662-84-2

Basic information

• Product Name: METHYL (6-CHLORO-2H-1 4-BENZOXAZIN-3(4H&
• Synonyms: METHYL (6-CHLORO-2H-1 4-BENZOXAZIN-3(4H&;methyl 2-(6-chloro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)acetate
• CAS NO: 104662-84-2
• Molecular Formula: C₁₁H₁₀ClNO₄
• Molecular Weight: 255.656
• Mol File: 104662-84-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 159-163 °C(lit.)
• Appearance: /
• CAS DataBase Reference: METHYL (6-CHLORO-2H-1 4-BENZOXAZIN-3(4H&(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (6-CHLORO-2H-1 4-BENZOXAZIN-3(4H&(104662-84-2)
• EPA Substance Registry System: METHYL (6-CHLORO-2H-1 4-BENZOXAZIN-3(4H&(104662-84-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 104662-84-2(Hazardous Substances Data)

Upstream product

• 108-31-6 maleic anhydride 
• 67-56-1 methanol 
• 95-85-2 2-hydroxy-5-chloro-aniline 

Downstream Products

• 134832-55-6 C₁₇H₁₄BrClN₄O₃S 
• 134832-54-5 C₁₇H₁₄Cl₂N₄O₃S 
• 134832-53-4 C₁₇H₁₄ClFN₄O₃S 
• 134832-63-6 2-[4-(4-Bromo-phenyl)-5-mercapto-4H-[1,2,4]triazol-3-ylmethyl]-6-chloro-4H-benzo[1,4]oxazin-3-one 
• 134832-62-5 6-chloro-2-(4-p-chlorophenyl-5-mercapto-5-4H,1,2,4-triazol-3-ylmethyl)benzoxazin-3-one 
• 134832-61-4 6-Chloro-2-[4-(4-fluoro-phenyl)-5-mercapto-4H-[1,2,4]triazol-3-ylmethyl]-4H-benzo[1,4]oxazin-3-one 
• 134832-52-3 C₁₇H₁₅ClN₄O₃S 
• 134832-60-3 6-Chloro-2-(5-mercapto-4-phenyl-4H-[1,2,4]triazol-3-ylmethyl)-4H-benzo[1,4]oxazin-3-one 
• 915725-01-8 (8-chloro-2-phenyl-4H-5-oxa-3,9b-diaza-cyclopenta[a]naphthalen-4-yl)-acetic acid methyl ester 
• 915724-91-3 [6-chloro-3-oxo-4-(2-oxo-2-phenyl-ethyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-acetic acid methyl ester 

Relevant articles and documents

A Convenient and One-Pot Synthesis of Methyl &α-(3,4-Dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)acetates

A convenient and one-step method for the preparation of methyl α-(6-substituted 3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)acetates (1a, and 8-14) is described.The reaction of appropriately substituted 2-aminophenols with maleic anhydride in the presence of Et3N gives the corresponding benzoxazinylacetates (1a and 8-10) while with methylmaleic anhydride, an initial nucleophilic attack at the more hindered carbonyl group takes place leading to the formation of the corresponding 2-methylbenzoxazinylacetates (11-14) in excellent yields.The antiinflammatory activity of these acetates (1a and 8-14) is also described.