104667-76-7

Upstream product

• 98-64-6 4-Chlorobenzenesulfonamide 
• 13068-12-7 N--4-chlorobenzenesulfonamide 
• 79-17-4 aminoguanidine 
• 104667-68-7 methyl N'-cyano-N-[(4-chlorophenyl)sulfonyl]imidothiocarbamate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 86147-15-1 1-acetyl-3,5-diamino-1H-1,2,4-triazole 
• 2582-30-1 aminoguanidine bicarbonate 

Relevant academic research and scientific papers

Functionalized azoles and triazolo[1,5-a]pyrimidines as latent leishmanicides

Triazolo[1,5-a]pyrimidine (3-6), benzoxazole (7a,b) and benzimidazole (7c) derivatives have been synthesized and evaluated for their in vitro leishmanicidal activity against L. donovani promastigotes.

Regioselective single-reactor synthesis of arylsulfonyl derivatives of 3,5-diamino-1,2,4-triazole

Arylsulfonylation of 1-acetyl-3,5-diamino-1,2,4-triazole with arylsulfonyl chlorides in pyridine, with the subsequent hydrolysis of the acetyl group, was studied; a new regioselective method for synthesis of N-(5-amino-1H-1,2,4- triazol-3-yl)arylsulfonami

A novel and efficient regiospecific preparation of arenesulfonamide derivatives of 3,5-diamino-1,2,4-triazole

A new simple and efficient procedure was designed for the regiospecific preparation of arenesulfonamide derivatives of 3,5-diamino-1,2,4-triazole 1 which are precursors of N-([1,2,4] triazolo [1,5-a]pyrimidin-2-yl)arenesulfonamides 2, an important family of herbicidal and antibacterial agents. The key feature of this procedure is the preparation of a wide range of compounds 1 on a large scale, in pure form and high yield without the need for any workup or the use of the highly hazardous hydrazine. This was made possible by a novel tandem reaction promoted by sulfuryl chloride to effect the formation of the triazole ring.

Regiospecific synthesis of N-sulfonyl derivatives of 3,5-diamino-1H-1,2,4-triazole and 2,5-diamino-1,3,4-thiadiazole

Condensation of the S,S-dimethyl N-(alkylsulfonyl)carbondithioimidates 1 with aminoguanidine bicarbonate and hydrazinecarbothioamide leads to the regiospecific synthesis of N-sulfonyl derivatives of 3,5-diamino-1H-1,2,4-triazole 2 and 2,5-diamino-1,3,4-thiadiazole 3, respectively.