1046758-77-3

Basic information

• Product Name: 2,2-difluoro-1-phenyl-2-(p-tosyl)ethanone
• Synonyms: 2,2-difluoro-1-phenyl-2-(p-tosyl)ethanone
• CAS NO: 1046758-77-3
• Molecular Weight: 310.321
• Mol File: 1046758-77-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-1-phenyl-2-(p-tosyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-1-phenyl-2-(p-tosyl)ethanone(1046758-77-3)
• EPA Substance Registry System: 2,2-difluoro-1-phenyl-2-(p-tosyl)ethanone(1046758-77-3)

Safety Data

• Hazardous Substances Data: 1046758-77-3(Hazardous Substances Data)

Upstream product

• 31378-03-7 1-phenyl-2-tosylethanone 
• 1256278-62-2 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 70-11-1 α-bromoacetophenone 
• 106-45-6 para-thiocresol 
• 33046-45-6 1-phenyl-2-(p-tolylthio)ethanone 

Relevant articles and documents

Preparation method of alpha, alpha-difluoro-beta-ketone sulfone compound

The invention provides a preparation method of an alpha, alpha-difluoro-beta ketone sulfone compound, and belongs to the technical field of chemistry. The invention firstly provides a composition forpreparing a compound shown as a formula I, which consists of the following components: a compound 1, a fluoride initiator and an organic solvent; Ar1 and Ar2 are independently selected from a substituted or unsubstituted aryl group and a substituted or unsubstituted heteroatom aryl group respectively. The invention also provides a method for preparing alpha, alpha-difluoro-beta-ketone sulfone compounds from the composition. According to the invention, metal fluoride is used as an initiator, and a series of compounds can be prepared under mild conditions. The preparation method is simple in synthetic route, good in yield and high in purity; the method has the advantages of excellent functional group adaptability and the like, can be used for preparing alpha, alpha-difluoro-beta-ketone sulfone compounds with various functional groups, and is successfully applied to later modification of natural products and drug molecules. Besides, the reaction scale of the method can be amplified to gram level, and the method can be used for industrial amplification production and has a good application prospect.

An efficient fluorination of β-ketosulfones promoted by a room-temperature ionic liquid at ambient conditions under ultrasound irradiation using Selectfluor F-TEDA-BF4

The fluorination reaction involving a β-ketosulfones by Selectfluor was efficiently promoted by the ionic liquid, [Hbim]BF4 (IL) as a reaction medium with methanol as co-solvent at room temperature under ultrasonic irradiation to afford the corresponding mono and difluoro-β-ketosulfones in excellent yields. The advantages of this method include among others the use of a recyclable, non-volatile ionic liquid, which promotes this protocol under room temperature without the requirement of any added catalyst under ultrasonic irradiation.