1256278-62-2

Upstream product

• 591-50-4 iodobenzene 
• 1256278-61-1 2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 
• 13652-13-6 toluene-4-sulfonic acid 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 569-72-2 1,1-difluoro-2,2-diphenylethylene 
• 1010720-52-1 1-(2,2-difluoro-1-phenylvinyl)-4-methylbenzene 
• 1010720-50-9 1-chloro-4-(2,2-difluoro-1-phenylvinyl)benzene 
• 1256278-84-8 2-(2,2-difluoro-1-phenylvinyl)furan 
• 1010720-58-7 1-(2,2-difluoro-1-phenylvinyl)-2-methylbenzene 
• 1262431-36-6 (Z)-2-fluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 1262431-35-5 (E)-2-fluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 1262431-37-7 2-(2-fluoro-1-phenylvinyl)naphthalene 
• 1262431-43-5 2-(2-fluoro-1-phenylvinyl)naphthalene 
• 1262431-38-8 (Z)-4-(2-fluoro-1-phenylvinyl)benzonitrile 
• 1262431-39-9 (E)-4-(2-fluoro-1-phenylvinyl)benzonitrile 
• 1262431-40-2 1-(2-fluoro-1-phenylvinyl)-4-(trifluoromethyl)benzene 
• 390-75-0 2-fluoro-1,1-diphenylethene 
• 1010720-53-2 1-(2,2-difluoro-1-phenylvinyl)-4-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Cross-Electrophile Coupling between Aryl/Vinyl Triflates and Vinyl Tosylates for the Synthesis of gem-Difluoroalkenes via Ni/Pd Cooperative Catalysis

A dual nickel-/palladium-catalyzed direct gem-difluorovinylation of readily available aryl/vinyl triflates with substituted gem-difluorovinyl tosylates is presented. This protocol affords various diaryldifluoroalkene, arylalkyldifluoroalkene and 1,1-diflu

Synthesis of 2,2-diaryl-1,1-difluoroethenes via Pd-catalyzed dehydrosulfonylative cross-coupling of α-[difluoro(phenylsulfonyl)methyl]benzyl tosylates with arylboronic acids

By using PhSO2CF2H as the difluoromethylidene equivalent, a novel method for connecting aromatic aldehydes and arylboronic acids via consecutive reactions was developed to obtain structurally diverse 2,2-diaryl-1,1-difluoroethenes. The key step is the palladium-catalyzed dehydrosulfonylative cross-coupling of tosylates that are prepared from PhSO2CF2H, aromatic aldehydes and tosyl chloride. Mechanistic investigations showed that the reaction proceeds mainly through base-mediated dehydrosulfonylation followed by palladium-catalyzed C(sp2)-C(sp2) cross-coupling reaction.

Consecutive cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate with boronic acids: Efficient synthesis of 1,1-diaryl-2,2-difluoroethenes

The cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate (2) with 2 equiv of boronic acids in the presence of catalytic amounts of Pd(OAc)2 and Na2CO3 afforded the mono-coupled products 3 and 5 in high yields. The use of 4 equiv of boronic acid

Monofluorovinyl tosylate: A useful building block for the synthesis of terminal vinyl monofluorides via suzuki-Miyaura coupling

Monofluorovinyl tosylate was developed as a practical vinyl fluoride building block to couple with a variety of arylboronic acids in the presence of a palladium catalyst. The high stereoselectivity of 2-aryl-1-fluoroethene derivatives was achieved. This a

Efficient synthesis of 2,2-diaryl-1,1-difluoroethenes via consecutive cross-coupling reactions of 2,2-difluoro-1-tributylstannylethenyl p -toluenesulfonate

2,2-Difluoro-1-tributylstannylethenyl p-toluenesulfonate (2) was reacted with aryl iodides in the presence of 10 mol % of Pd(PPh3)4 and 10 mol % of CuI in DMF at 80 °C for 10-20 h to give the cross-coupled products 3 in 35-97% yields. Further coupling reaction of 3 with arylstannanes in the presence of 5 mol % of Pd(PPh3)4 and 3 equiv of LiBr in DMF at 100 °C for 2-24 h afforded the desired products 5 in 25-78% yields.