104678-17-3

Upstream product

• 58841-52-4 2-(benzyloxy)ethyl methanesulfonate 
• 75-04-7 ethylamine 
• 60656-87-3 benzyloxyacetoaldehyde 

Downstream Products

• 883973-93-1 (S)-2-[3-(2-Benzyloxy-ethyl)-3-ethyl-ureido]-3-phenyl-propionic acid methyl ester 
• 553672-20-1 N-[2-(benzyloxy)ethyl]-N-ethylamine hydrochloride 
• 883973-48-6 2-[3-(2-benzyloxy-ethyl)-3-ethyl-ureido]-N-methoxy-N-methyl-3-phenyl-propionamide 
• 883973-37-3 (S)-2-[3-(2-Benzyloxy-ethyl)-3-ethyl-ureido]-3-phenyl-propionic acid 

Relevant academic research and scientific papers

A novel series of urea-based peptidomimetic calpain inhibitors

A series of peptide aldehyde derivatives in which the P2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of μ-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for μ-calpain over cathepsin B.

PYRAZOLOPYRIMIDINONE DERIVATIVES HAVING PDE7?INHIBITORY ACTIVITY

Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB): and the following general formula (IA') or (IB'): where the symbols are as disclosed in the specification, are provided as desired compounds. These compounds have the action of selectively inhibiting PDE7, thereby increasing the intracellular cAMP level and inhibiting the activation of T cells. Thus, they are useful for prevention and treatment of various allergic diseases and inflammatory or immunological diseases.