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10468-90-3

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10468-90-3 Usage

Chemical Properties

Tan-to-Light Brown Solid

Uses

Different sources of media describe the Uses of 10468-90-3 differently. You can refer to the following data:
1. A metabolite of thyroid hormone. Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus
2. A metabolite of thyroid hormone. Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Check Digit Verification of cas no

The CAS Registry Mumber 10468-90-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,6 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10468-90:
(7*1)+(6*0)+(5*4)+(4*6)+(3*8)+(2*9)+(1*0)=93
93 % 10 = 3
So 10468-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H14INO4/c16-12-7-9(8-13(17)15(19)20)1-6-14(12)21-11-4-2-10(18)3-5-11/h1-7,13,18H,8,17H2,(H,19,20)/t13-/m0/s1

10468-90-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3-iodophenyl]propanoic acid

1.2 Other means of identification

Product number -
Other names 3-monoiodothyronine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10468-90-3 SDS

10468-90-3Relevant articles and documents

Varcoe,Warburton

, p. 2711,2714 (1960)

Biomimetic deiodination of thyroid hormones and iodothyronamines-a structure-activity relationship study

Mondal, Santanu,Mugesh, Govindasamy

supporting information, p. 9490 - 9500 (2016/10/22)

Mammalian selenoenzymes, iodothyronine deiodinases (DIOs), catalyze the tyrosyl and phenolic ring deiodination of thyroid hormones (THs) and play an important role in maintaining the TH concentration throughout the body. These enzymes also accept the decarboxylated thyroid hormone metabolites, iodothyronamines (TAMs), as substrates for deiodination. Naphthalene-based selenium and/or sulphur-containing small molecules have been shown to mediate the regioselective tyrosyl ring deiodination of thyroid hormones and their metabolites. Herein, we report on the structure-activity relationship studies of a series of peri-substituted selenium-containing naphthalene derivatives for the deiodination of thyroid hormones and iodothyronamines. Single crystal X-ray crystallographic and 77Se NMR spectroscopic studies indicated that the intramolecular Se?X (X = N, O and S) interactions play an important role in the deiodinase activity of the synthetic mimics. Furthermore, the decarboxylated metabolites, TAMs, have been observed to undergo slower tyrosyl ring deiodination than THs by naphthyl-based selenium and/or sulphur-containing synthetic deiodinase mimics and this has been explained on the basis of the strength of Se?I halogen bonding formed by THs and TAMs.

Catalytic tritiation of iodized phenols. Preparation of tritiated estradiol, tyrosine and thyronine.

JACQUEMIN,MICHEL,NUNEZ,ROCHE

, p. 1904 - 1906 (2007/11/09)

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