1046817-22-4

Basic information

• Product Name: 1-methylcyclopropyl 4-nitrophenyl carbonate
• Synonyms: 1-methylcyclopropyl 4-nitrophenyl carbonate;4-Nitrophenyl 1-methylcyclopropyl carbonate
• CAS NO: 1046817-22-4
• Molecular Formula: C₁₁H₁₁NO₅
• Molecular Weight: 237
• Mol File: 1046817-22-4.mol

Chemical Properties

• Melting Point: 46-48℃
• Appearance: /
• Density: 1.35±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-methylcyclopropyl 4-nitrophenyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylcyclopropyl 4-nitrophenyl carbonate(1046817-22-4)
• EPA Substance Registry System: 1-methylcyclopropyl 4-nitrophenyl carbonate(1046817-22-4)

Safety Data

• Hazardous Substances Data: 1046817-22-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry Research:
1-Methylcyclopropyl 4-nitrophenyl carbonate is used as a research compound for exploring its chemical properties and reactivity. Its unique structure allows chemists to study its behavior in various organic reactions and potentially discover new applications in chemical synthesis.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 1-Methylcyclopropyl 4-nitrophenyl carbonate may be employed as an intermediate or a building block in the synthesis of pharmaceutical compounds. Its specific functional groups can be utilized in the development of new drugs, targeting various therapeutic areas.
Used in Chemical Synthesis:
1-Methylcyclopropyl 4-nitrophenyl carbonate is used as a reagent or precursor in the synthesis of other organic compounds. Its structural features can be exploited to form new chemical entities with potential applications in various industries, such as materials science, agrochemicals, or specialty chemicals.
Used in Material Science:
In the field of material science, 1-Methylcyclopropyl 4-nitrophenyl carbonate may be utilized in the development of new materials with specific properties. Its incorporation into polymers or other materials could lead to the creation of novel materials with improved characteristics, such as enhanced stability, reactivity, or specific functional properties.

Upstream product

• 29526-99-6 1-methylcyclopropanol 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 121-44-8 triethylamine 

Downstream Products

• 1264295-31-9 1-methylcyclopropyl 4-(7-(1-ethoxy-2-methyl-1-oxo-3-phenylpropan-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1416175-52-4 1-methylcyclopropyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate 
• 1578188-53-0 4-{[4-(3-cyano-pyridin-4-yl)-benzoyl]-cyclopropyl-amino}-piperidine-1-carboxylic acid 1-methyl-cyclopropyl ester 
• 1451163-47-5 4-[5-(2-fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid 1-methyl-cyclopropyl ester 
• 1376610-86-4 4-({2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carbonyl}(ethyl)amino)piperidine-1-carboxylic acid 1-methylcyclopropyl ester 
• 1417392-22-3 C₂₅H₂₉FN₄O₅S 
• 1310458-30-0 C₁₈H₂₄N₂O₃ 
• 1310458-29-7 C₁₈H₂₄N₂O₃ 
• 1134113-02-2 1-methylcyclopropyl 4-((4-bromo-2,6-difluorophenoxy)methyl)piperidine-1-carboxylate 
• 1204129-46-3 1-methylcyclopropyl 4-((3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)methyl)piperidine-1-carboxylate 
• 1190979-27-1 1-methylcyclopropyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate 
• 1381977-60-1 (S)-1-methylcyclopropyl 4-(1-(4-chlorophenyl)-4-(3-phenylpyrrolidine-1-carbonyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate 
• 1379603-76-5 1-methylcyclopropyl 4-{5-cyano-4-[(4-cyano-2-fluorophenoxy)methyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate 
• 1272973-08-6 1-methylcyclopropyl 4-(5-(4-(methylsulfonyl)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate 

Relevant articles and documents

Study of the kulinkovich synthesis of 1-methylcyclopropanol and its conversion into 1-methylcyclopropyl 4-nitrophenyl carbonate

A detailed investigation of the preparation of 1-methylcyclopropanol via the Kulinkovich reaction is presented. Reaction and workup parameters were optimized to provide a reproducible procedure for the synthesis of multigram quantities of 1-methylcyclopropanol. Key improvements were the use of titanium tetra(2-ethyl)hexyloxide as catalyst, reduction in the volume of reaction solvent, addition of the methyl acetate starting material in portions, and azeotropic distillation to remove by-products. The preparation of the 4-nitrophenyl carbonate ester was likewise studied and optimized. Georg Thieme Verlag Stuttgart New York.

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