1046817-22-4

Basic information

• Product Name: 1-methylcyclopropyl 4-nitrophenyl carbonate
• Synonyms: 1-methylcyclopropyl 4-nitrophenyl carbonate;4-Nitrophenyl 1-methylcyclopropyl carbonate
• CAS NO: 1046817-22-4
• Molecular Formula: C₁₁H₁₁NO₅
• Molecular Weight: 237
• Mol File: 1046817-22-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 46-48℃
• Appearance: /
• Density: 1.35±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-methylcyclopropyl 4-nitrophenyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylcyclopropyl 4-nitrophenyl carbonate(1046817-22-4)
• EPA Substance Registry System: 1-methylcyclopropyl 4-nitrophenyl carbonate(1046817-22-4)

Safety Data

• Hazardous Substances Data: 1046817-22-4(Hazardous Substances Data)

Usage

General Description

1-Methylcyclopropyl 4-nitrophenyl carbonate is a chemical compound used primarily in the field of organic chemistry. Its structural formula includes a methylcyclopropyl group, which is a three-carbon ring with a methyl (CH3) group attached, and a 4-nitrophenyl carbonate group, made up of a phenyl ring with a nitro (NO2) group at the 4-position and a carbonate (CO3) group attached. The exact properties of this chemical, including its reactivity, stability, and potential uses, depend on its specific structural configuration and are subject to study and analysis in a laboratory setting. As with any chemical, proper safety measures should be taken to handle and store 1-Methylcyclopropyl 4-nitrophenyl carbonate.

Upstream product

• 29526-99-6 1-methylcyclopropanol 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 121-44-8 triethylamine 

Downstream Products

• 1416175-52-4 1-methylcyclopropyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate 
• 1451163-47-5 4-[5-(2-fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid 1-methyl-cyclopropyl ester 
• 1376610-86-4 4-({2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carbonyl}(ethyl)amino)piperidine-1-carboxylic acid 1-methylcyclopropyl ester 
• 1417392-22-3 C₂₅H₂₉FN₄O₅S 
• 1381977-60-1 (S)-1-methylcyclopropyl 4-(1-(4-chlorophenyl)-4-(3-phenylpyrrolidine-1-carbonyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate 
• 1379603-76-5 1-methylcyclopropyl 4-{5-cyano-4-[(4-cyano-2-fluorophenoxy)methyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate 
• 1310458-30-0 C₁₈H₂₄N₂O₃ 
• 1310458-29-7 C₁₈H₂₄N₂O₃ 
• 1272973-08-6 1-methylcyclopropyl 4-(5-(4-(methylsulfonyl)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate 
• 1280608-09-4 C₂₀H₂₄F₄N₂O₃ 
• 1264295-31-9 1-methylcyclopropyl 4-(7-(1-ethoxy-2-methyl-1-oxo-3-phenylpropan-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1258001-69-2 1-methylcyclopropyl 4-{4-[(4-carbamoyl-2-fluorophenoxy)methyl]-5-cyano-1H-pyrazol-1-yl}piperidine-1-carboxylate 
• 1258001-65-8 1-methylcyclopropyl 4-{5-cyano-4-[(2,5-difluorophenoxy)methyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate 
• 1134113-02-2 1-methylcyclopropyl 4-((4-bromo-2,6-difluorophenoxy)methyl)piperidine-1-carboxylate 

Relevant articles and documents

Study of the kulinkovich synthesis of 1-methylcyclopropanol and its conversion into 1-methylcyclopropyl 4-nitrophenyl carbonate

A detailed investigation of the preparation of 1-methylcyclopropanol via the Kulinkovich reaction is presented. Reaction and workup parameters were optimized to provide a reproducible procedure for the synthesis of multigram quantities of 1-methylcyclopropanol. Key improvements were the use of titanium tetra(2-ethyl)hexyloxide as catalyst, reduction in the volume of reaction solvent, addition of the methyl acetate starting material in portions, and azeotropic distillation to remove by-products. The preparation of the 4-nitrophenyl carbonate ester was likewise studied and optimized. Georg Thieme Verlag Stuttgart New York.

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