104683-00-3

Upstream product

• 29289-13-2 2-iodo-4-methylaniline 
• 536-74-3 phenylacetylene 
• 13141-44-1 4-methyl-2-(phenylethynyl)aniline 
• 108-24-7 acetic anhydride 
• 29289-16-5 N-(2-iodo-4-methylphenyl)acetamide 
• 1241049-33-1 C₁₇H₁₅NO 
• 614-83-5 2-bromo-4-methylacetanilide 
• 3757-88-8 tributylstannylethynylbenzene 
• 13146-23-1 copper(I) phenylacetylenide 
• 101010-07-5 C₁₃H₁₀F₆NO₅Tl 

Downstream Products

• 1241049-21-7 1-(3-chloro-5-methyl-2-phenyl-1H-indol-1-yl)ethanone 
• 13228-36-9 5-methyl-2-phenyl-1H-indole 
• 104683-04-7 1-(5-methyl-2-phenyl-1H-indol-1-yl)ethan-1-one 

Relevant academic research and scientific papers

Nickel-Catalyzed Arylative Additions on 2-Alkynyl-N-Arylsulfonylanilides to Construct Functionalized Indoles

The addition of aryl iodides to 2-alkynyl-N-sulfonylanilides to form 2,3-difunctionalized N-arylsulfonylindoles can be catalyzed using a nickel catalyst ligated to a bis(cyclohexanyl)phosphinoferrocene. A variety of nickel complexes can be used as precata

PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramolecular hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1–2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates.

Multicatalytic one-pot reaction of 1-(2-alkynylphenyl)ketoximes for generation of indole derivatives

Multicatalytic one-pot Beckmann rearrangement/intramolecular cyclization/halogenation reaction of 1-(2-alkynylphenyl)ketoxime is reported, leading to the expected indole derivatives in good yield.

THALLIUM IN ORGANIC SYNTHESIS. 68. A CONVENIENT SYNTHESIS OF 2-PHENYLINDOLES FROM ANILIDES

Thallation of anilides with TTFA in a mixture of TFA and ether gives ortho-thallated derivatives, which yield 2-acetamidotolanes upon reaction with copper (I) phenylacetylide in acetonitrile.Treatment of the latter compounds with palladium(II) chloride results in ring closure to give 1-acyl-2-phenylindoles, from which 2-phenylindoles are obtained by alkaline hidrolysis.