104705-98-8

Upstream product

• 104705-97-7 (3RS,4RS)-3,4-dihydro-3-<(3R)-7-<(2R,4R,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-2-yl>-3,5-dimethyl-1(E),5(EZ)-heptadien-1-yl>-6-methoxy-4,7-dimethyl-2(1H)-benzopyran-1-one 
• 102740-19-2 ethyl 2-ethyl-4-hydroxy-5-methyl benzoate 
• 102740-25-0 2-ethyl-4-methoxy-5-methylbenzoic acid 
• 102740-24-9 ethyl 2-ethyl-4-methoxy-5-methylbenzoate 
• 104705-91-1 2-<(2S,4R,6R,8R,9S)-4-<(tert-butyldiphenylsilyl)oxy>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecyl>ethanal 
• 104996-39-6 (2R,4R,6R,8R,9S)-4-<(tert-butyldiphenylsilyl)oxy>-2-(2-hydroxyethyl)-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 82045-38-3 2-[(E)-3-(Diphenyl-phosphinoyl)-1-methyl-propenyl]-4-methoxy-5-methyl-benzoic acid methyl ester 
• 928-90-5 5-hexyl-1-ol 
• 912457-37-5 (E)-3-{(4R,5R)-5-[2-(4-Methoxy-phenoxy)-ethyl]-2-oxo-[1,3]dioxolan-4-yl}-acrylic acid ethyl ester 
• 912457-49-9 6-(4-methoxyphenoxy)hex-1-yne 
• 912457-45-5 (2R)-2-allyloxy-1-{(2R,4R,6R,8R,9S)-4-[tert-butyl(diphenyl)silyloxy]-8,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl}-3-methylbut-3-ene 
• 912457-52-4 (2S,4R,6R,8R,9S)-4-[tert-butyl(diphenyl)silyloxy]-8,9-dimethyl-2-[2-(4-methoxyphenoxy)ethyl]-1,7-dioxaspiro[5.5]undecane 
• 912457-44-4 (2R)-1-{(2R,4R,6R,8R,9S)-4-[tert-butyl(diphenyl)silyloxy]-8,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl}-3-methylbut-3-en-2-ol 
• 912457-34-2 dimethyl 3-{(2R,4R,6R)-6-[2-(4-methoxyphenoxy)ethyl]-2-phenyl-1,3-dioxan-4-yl}-2-oxopropyl-phosphonate 

Relevant academic research and scientific papers

De novo asymmetric synthesis of milbemycin β3 via an iterative asymmetric hydration approach

The enantioselective synthesis of the spiroketal/macrolide natural product milbemycin β3 has been achieved in 22 steps and 2.8% overall yield from an achiral dienoate. The spiroketal ring system was installed by three sequential asymmetric hydr

Total Synthesis of (+)-Milbemycin β3

(+)-Milbemycin β3 (1) was prepared by total synthesis from (6S,8R,9S)-methyl 8,9-dimethyl-4-oxo-1,7-dioxaspiroundec-2-ene-2-carboxylate (2), (4R,6R)-4-methyl-6-phenylsulphonyl-(E)-hept-2-en-1-ol (3a), and 2-ethyl-4-methoxy-5-methylbenzoic