104705-91-1Relevant academic research and scientific papers
De novo asymmetric synthesis of milbemycin β3 via an iterative asymmetric hydration approach
Li, Miaosheng,O'Doherty, George A.
, p. 3987 - 3990 (2007/10/03)
The enantioselective synthesis of the spiroketal/macrolide natural product milbemycin β3 has been achieved in 22 steps and 2.8% overall yield from an achiral dienoate. The spiroketal ring system was installed by three sequential asymmetric hydr
Total Synthesis of (+)-Milbemycin β3
Baker, Raymond,O'Mahony, Mary J.,Swain, Christopher J.
, p. 1623 - 1634 (2007/10/02)
The total synthesis of (+)-milbemycin β3 has been achieved in two ways beginning from the appropriate spiroacetal moiety.In the first, coupling of a vinyl-lithium derivative (18) with the spiroacetal aldehyde (19), available from Swern oxidatio
Total Synthesis of (+)-Milbemycin β3
Attwood, Stephen V.,Barrett, Anthony G. M.,Carr, Robin A. E.,Richardson, Geoffrey
, p. 479 - 481 (2007/10/02)
(+)-Milbemycin β3 (1) was prepared by total synthesis from (6S,8R,9S)-methyl 8,9-dimethyl-4-oxo-1,7-dioxaspiroundec-2-ene-2-carboxylate (2), (4R,6R)-4-methyl-6-phenylsulphonyl-(E)-hept-2-en-1-ol (3a), and 2-ethyl-4-methoxy-5-methylbenzoic
A FORMAL SYNTHESIS OF (+)MILBEMYCIN β3: A WITTIG APPROACH
Baker, Raymond,O'Mahony, Mary J.,Swain, Christopher J.
, p. 3059 - 3062 (2007/10/02)
A new route has been established to generate the C14-C15 trisubstituted double bond of milbemycin β3 by reaction of a Wittig reagent with the appropriate spiroacetal aldehyde.The product of this reaction, after conversion to the iodide and enan
