912457-49-9

Upstream product

• 928-90-5 5-hexyl-1-ol 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 912457-36-4 ethyl 7-(4-methoxyphenoxy)hept-2-ynoate 
• 77376-81-9 (3,5-dimethoxyphenyl) 7-hydroxyhexyl ketone 
• 104705-98-8 2-<(5R)-9-<(2R,4R,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxaspiro<5.5>undec-1-yl>-1,5,7-trimethyl-1(E),3(E),7(Z)-nonatrien-1-yl>-4-methoxy-5-methylbenzoic acid 
• 104705-91-1 2-<(2S,4R,6R,8R,9S)-4-<(tert-butyldiphenylsilyl)oxy>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecyl>ethanal 
• 104996-39-6 (2R,4R,6R,8R,9S)-4-<(tert-butyldiphenylsilyl)oxy>-2-(2-hydroxyethyl)-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 912457-45-5 (2R)-2-allyloxy-1-{(2R,4R,6R,8R,9S)-4-[tert-butyl(diphenyl)silyloxy]-8,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl}-3-methylbut-3-ene 
• 912457-52-4 (2S,4R,6R,8R,9S)-4-[tert-butyl(diphenyl)silyloxy]-8,9-dimethyl-2-[2-(4-methoxyphenoxy)ethyl]-1,7-dioxaspiro[5.5]undecane 
• 912457-44-4 (2R)-1-{(2R,4R,6R,8R,9S)-4-[tert-butyl(diphenyl)silyloxy]-8,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl}-3-methylbut-3-en-2-ol 
• 912457-34-2 dimethyl 3-{(2R,4R,6R)-6-[2-(4-methoxyphenoxy)ethyl]-2-phenyl-1,3-dioxan-4-yl}-2-oxopropyl-phosphonate 
• 912457-33-1 (3E,5Z)-1-{(2R,4R,6R)-6-[2-(4-methoxyphenoxy)ethyl]-2-phenyl-1,3-dioxan-4-yl}-5-methylhepta-3,5-dien-2-one 
• 912457-40-0 N-methoxy-N-methyl-2-{(2R,4R,6R)-6-[2-(4-methoxyphenoxy)ethyl]-2-phenyl-1,3-dioxan-4-yl}acetamide 

Relevant academic research and scientific papers

De novo asymmetric synthesis of milbemycin β3 via an iterative asymmetric hydration approach

The enantioselective synthesis of the spiroketal/macrolide natural product milbemycin β3 has been achieved in 22 steps and 2.8% overall yield from an achiral dienoate. The spiroketal ring system was installed by three sequential asymmetric hydr

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

We report the synthesis of terminally fluorinated HU-210 and HU-211 analogues (HU-210F and HU-211F, respectively) and their biological evaluation as ligands of cannabinoid receptors (CB1 and CB2) and N-methyl d-aspartate receptor (NMDAR). [18F]-labelled HU-210F was radiosynthesised from the bromo-substituted precursor. In vitro assays showed that both HU-210F and HU-211F retain the potent pharmacological profile of HU-210 and HU-211, suggesting that [18F]-radiolabelled HU-210F and HU-211F could have potential as PET tracers for in vivo imaging.