104713-83-9Relevant academic research and scientific papers
Alkylation studies of a polyhydroxylated-cyano-piperidine scaffold
Dilmac, Alicia M.,Tite, Tony,Tsimilaza, Andriamihamina,Lemoine, Pascale,Boutefnouchet, Sabrina,Michel, Sylvie,Lallemand, Marie-Christine
, p. 24 - 37 (2014)
Hexahydro-3-phenyl-6,7,8-trihydroxy-3R-[3α,5β,6β,7α, 8β,8aβ]-5H-oxazolo[3,2-a]pyridine-5- carbonitrile is endowed with two non equivalent reactive sites: an α-amino nitrile at the C-5 position and an α-amino ether at the C-8a position. Herein, alkylation
Reductive and oxidative transformations of the N-(cyanomethyl)oxazolidine system to expand the chiral pool of piperidines
Francois, David,Poupon, Erwan,Kunesch, Nicole,Husson, Henri-Philippe
, p. 4823 - 4829 (2007/10/03)
Two new reactions have been exploited to modify piperidine scaffolds containing the chiral, non-racemic N-(cyanomethyl)oxazolidine system. A Raney nickel mediated decyanation was studied first, followed by an oxidative process using potassium permanganate
