104719-63-3

Basic information

• Product Name: BOC-D-GLU(OTBU)-OH
• Synonyms: BOC-D-GLUTAMIC ACID-GAMMA-T-BUTYL ESTER;BOC-D-GLUTAMIC ACID(OTBU)-OH;BOC-D-GLUTAMIC ACID 5-TERT-BUTYL ESTER;BOC-D-GLU(OTBU)-OH;N-T-BUTOXYCARBONYL-D-GLUTAMIC ACID GAMMA-T-BUTYL ESTER;N-ALPHA-T-BOC-D-GLUTAMIC ACID GAMMA-T-BUTYL ESTER;N-tert-Butoxycarbonyl-D-glutamic acid 5-tert-butyl ester;BOC-D-GLUTAMIC ACID-Y-T-BUTYLESTER
• CAS NO: 104719-63-3
• Molecular Formula: C₁₄H₂₅NO₆
• Molecular Weight: 303.35
• Product Categories: Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 104719-63-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 449.8 °C at 760 mmHg
• Flash Point: 225.8 °C
• Appearance: /Solid
• Density: 1.121
• Vapor Pressure: 2.42E-09mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: 2-8°C
• PKA: 3.82±0.10(Predicted)
• BRN: 3594191
• CAS DataBase Reference: BOC-D-GLU(OTBU)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-GLU(OTBU)-OH(104719-63-3)
• EPA Substance Registry System: BOC-D-GLU(OTBU)-OH(104719-63-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 104719-63-3(Hazardous Substances Data)

Usage

Uses

N-Boc-D-glutamic Acid 5-tert-Butyl Ester is used as a reactant in the synthesis of peptides.

InChI:InChI=1/C14H25NO6/c1-13(2,3)20-10(16)8-7-9(11(17)18)15-12(19)21-14(4,5)6/h9H,7-8H2,1-6H3,(H,15,19)(H,17,18)/t9-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 129016-14-4 (E)-(R)-4-tert-Butoxycarbonylamino-5-hydroxy-pent-2-enoic acid tert-butyl ester 
• 129016-13-3 ((1S,2R,3S,4R)-2,3,4,5-Tetrahydroxy-1-hydroxymethyl-pentyl)-carbamic acid tert-butyl ester 
• 91103-36-5 N-tert.-butyloxycarbonyl-L-serinal 
• 130333-58-3 1,1-dimethylethyl (4R)-4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-hydroxypentanoate 

Downstream Products

• 66575-26-6 (R)-iso-glutamine t-butyl ester hydrochloride 
• 1370749-26-0 tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-3-(tert-butoxycarbonyl)propyl]carbamate 
• 1370748-99-4 4-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-4-(benzo[d]oxazol-2-yl)butanoic acid 
• 1269619-42-2 (R)-1-benzyl 5-tert-butyl 2-((tert-butoxycarbonyl)amino)pentanedioate 
• 204251-86-5 (R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(allyloxy)-5-oxopentanoic acid 
• 104091-10-3 (R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanoic acid 
• 79338-14-0 D-glutamic acid 1-benzyl ester 
• 1269620-19-0 (S)-tert-butyl 6-((R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamido)-2-((tert-butoxycarbonyl)amino)hexanoate 
• 1269620-15-6 (S)-tert-butyl 2-((R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamido)-6-(((benzyloxy)carbonyl)amino)hexanoate 
• 1269620-11-2 (R)-benzyl 6-((R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamido)-2-(((benzyloxy)carbonyl)amino)hexanoate 
• 1269620-06-5 (R)-benzyl 2-((R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)hexanoate 
• 1269620-04-3 (2R)-benzyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-((2-oxoazepan-3-yl)amino)pentanoate 
• 1269620-02-1 (R)-benzyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((5-((tertbutoxycarbonyl)amino)pentyl)amino)-5-oxopentanoate 
• 1269620-00-9 dibenzyl 2-((R)-4-(((-(9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamido)heptanedioate 

Relevant articles and documents

Chirospecific synthesis of amino acids, amino aldehydes and amino alcohols from D-glucosamine hydrochloride. A multigram synthesis of N-BOC-L-serinal

N-tert.-butyloxycarbonyl-L-serinal 4 was readily prepared from D-glucosamine hydrochloride 1 in three steps. The versatile synthetic intermediate 4 is chemically and configurationally stable for prolonged time and reacts with various stabilized phosphorus