179082-63-4Relevant academic research and scientific papers
Oxoazepine derivatives
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, (2008/06/13)
This invention relates to novel oxoazepine derivatives of Formula (I), to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. More particularly, it relates to compounds which exhibit agonist ac
Conversion of acyclic nonpeptide CCK antagonists into CCK agonists
Hirst, Gavin C.,Queen, Kennedy L.,Sugg, Elizabeth E.,Willson, Timothy M.
, p. 511 - 514 (2007/10/03)
The CCK antagonists RP 69758 and (R)-lorglumide were converted into CCK agonists by the introduction of an N-isopropylanilide agonist 'trigger'. The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor.
