104746-49-8

Upstream product

• 104746-48-7 3,3,7,11-Tetramethyl-6,10-dodecadien-1-al 
• 3790-67-8 2,6-(E,Z)-farnesal 
• 104746-47-6 (Z)-3,3,7,11-tetramethyldodeca-6,10-dienal 
• 3879-60-5 2E,6Z-farnesol 
• 4380-32-9 (2Z,6E)-farnesal 
• 3790-68-9 (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trienal 
• 3790-71-4 (2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol 
• 16106-95-9 (2Z,6Z)-farnesol 

Downstream Products

• 107259-72-3 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2R)-5,5-dimethyl-2-(5-methyl-1-methylene-hex-4-enyl)-cyclohexyl ester 
• 107259-72-3 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-5,5-dimethyl-2-(5-methyl-1-methylene-hex-4-enyl)-cyclohexyl ester 

Relevant academic research and scientific papers

MANUFACTURING METHOD OF OPTICAL ACTIVE ALCOHOL

PROBLEM TO BE SOLVED: To provide a method for providing optical active alcohol capable of being a perfume material or a cold sensation raw material with high optical purity and high selectivity by conducting an asymmetric carbonyl-en ring closure reaction

BINOL-Al catalysed asymmetric cyclization and amplification: Preparation of optically active menthol analogs

We report a highly selective asymmetric ring-closing ene reaction catalysed by aluminum complexes with chiral BINOL. This reaction yields optically active 6-membered cyclized alcohols from unsaturated aldehydes, with good diastereo- and enantioselectiviti

ASYMMETRIC CYCLIZATION OF UNSATURATED ALDEHYDES CATALYZED BY A CHIRAL LEWIS ACID

A highly enantioselective cyclization of unsaturated aldehydes has been accomplished with the chiral zinc reagent 1 derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol.Thus, the Aldehyde 2 and 10 are treated with the reagent 1 producing the trans alcohol 3 and 11, respectively, with high optical purity (>90percent ee).In sharp contrast, the aldehyde 8 affords the totally racemic alcohol 9.Since the chiral zinc reagent 1 possesses its C2-symmetry, either enantiomer can be prepared from the unsaturated aldehyde by choosing the chiral ligand, (R)-(+)- or (S)-(-)-1,1'-bi-2-naphthol.

ASYMMETRIC CYCLIZATION OF UNSATURATED ALDEHYDES CATALYZED BY A CHIRAL LEWIS ACID

A highly enantioselective cyclization of prochiral unsaturated aldehydes has been accomplished with a chiral zinc reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol.