107259-72-3

Upstream product

• 104746-48-7 3,3,7,11-Tetramethyl-6,10-dodecadien-1-al 
• 104746-47-6 (Z)-3,3,7,11-tetramethyldodeca-6,10-dienal 
• 4380-32-9 (2Z,6E)-farnesal 
• 3790-68-9 (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trienal 
• 3790-71-4 (2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol 
• 16106-95-9 (2Z,6Z)-farnesol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 104746-49-8 (1S,2R)-5,5-dimethyl-2-(6-methylhepta-1,5-dien-2-yl)cyclohexanol 

Relevant academic research and scientific papers

ASYMMETRIC CYCLIZATION OF UNSATURATED ALDEHYDES CATALYZED BY A CHIRAL LEWIS ACID

A highly enantioselective cyclization of unsaturated aldehydes has been accomplished with the chiral zinc reagent 1 derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol.Thus, the Aldehyde 2 and 10 are treated with the reagent 1 producing the trans alcohol 3 and 11, respectively, with high optical purity (>90percent ee).In sharp contrast, the aldehyde 8 affords the totally racemic alcohol 9.Since the chiral zinc reagent 1 possesses its C2-symmetry, either enantiomer can be prepared from the unsaturated aldehyde by choosing the chiral ligand, (R)-(+)- or (S)-(-)-1,1'-bi-2-naphthol.