104774-81-4

Basic information

• Product Name: methyl 2-acrylamidobenzoate
• Synonyms: methyl 2-acrylamidobenzoate
• CAS NO: 104774-81-4
• Molecular Weight: 205.213
• Mol File: 104774-81-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 2-acrylamidobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-acrylamidobenzoate(104774-81-4)
• EPA Substance Registry System: methyl 2-acrylamidobenzoate(104774-81-4)

Safety Data

• Hazardous Substances Data: 104774-81-4(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 814-68-6 acryloyl chloride 
• 16714-23-1 2-azido-benzoic acid methyl ester 
• 89431-22-1 ethyl prop-2-ynyl methylphosphonate 

Downstream Products

• 1229020-95-4 C₃₀H₄₇N₃O₄ 
• 1146206-16-7 C₂₃H₂₀N₂O₄ 

Relevant articles and documents

Concurrent pathway and unexpected products in the CuAAC reaction of ethyl prop-2-ynyl methylphosphonate with aromatic azides

[Figure not available: see fulltext.] The CuI-mediated click reaction of aromatic azides, containing the carboxyl moiety in the ortho position to the azido group, with ethyl prop-2-ynyl methylphosphonate proceeded via a concurrent pathway whereby the form

Pyrazole derivative for FGFR inhibitor and preparation method of pyrazole derivative

The invention provides a pyrazole derivative for an FGFR inhibitor and a preparation method of the pyrazole derivative. The invention specifically relates to an amide pyrazole compound serving as an FGFR irreversible inhibitor, and a preparation method and application thereof. The present invention provides a compound as shown in Formula I, or a pharmaceutically acceptable salt, or solvate, isotope substitute, prodrug, or metabolite thereof. The compound as shown in general formula I have FGFR inhibitory activity, and is capable of preventing or treating disorders associated with FGFR activityor expression, preferably such as cancer.

Systematic study of the glutathione (GSH) reactivity of N-arylacrylamides: 1. Effects of aryl substitution

Success in the design of targeted covalent inhibitors depends in part on a knowledge of the factors influencing electrophile reactivity. In an effort to further develop an understanding of structure-reactivity relationships among N-arylacrylamides, we determined glutathione (GSH) reaction rates for a family of N-arylacrylamides independently substituted at ortho-, meta-, and para-positions with 11 different groups common to inhibitor design. We find that substituent effects on reaction rates show a linear Hammett correlation for ortho-, meta-, and para-substitution. In addition, we note a correlation between 1H and 13C NMR chemical shifts of the acrylamide with GSH reaction rates, suggesting that NMR chemical shifts may be a convenient surrogate measure of relative acrylamide reactivity. Density functional theory calculations reveal a correlation between computed activation parameters and experimentally determined reaction rates, validating the use of such methodology for the screening of synthetic candidates in a prospective fashion.