1047974-97-9

Upstream product

• 79-33-4 L-Lactic acid 
• 98-88-4 benzoyl chloride 
• 27871-49-4 (S)-Methyl lactate 

Downstream Products

• 1352613-24-1 (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester (S)-O-benzoyl lactate 
• 1126974-98-8 C₃₀H₄₆N₂O₈ 

Relevant academic research and scientific papers

Ruthenium-catalyzed enantioselective reduction of electron-rich aryl alkyl ketones

Presented here is the investigation of the transfer hydrogenation of electron-rich aryl alkyl ketones using ruthenium complexes of dipeptide-like ligands and 2-propanol as hydride source. The reduction proceeded with excellent selectivity (up to > 99% ee) and in moderate to high yields (up to 90%).

METHOD FOR PRODUCING TRIAZOLE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel method for producing a triazole compound useful as a pharmaceutical intermediate. SOLUTION: A production method includes reacting a lactic acid derivative with thionyl chloride, then reacting it with 1,3-difluoro benzene in the presence of Al chloride to obtain a ketone derivative, which is turned into an olefin with a Wittig reagent to be derived into compound (2), and it is then turned into an epoxy and a triazole to be derived into compound (1). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT