104798-53-0

Usage

Chemical Properties

off-white crytalline

InChI:InChI=1/C7H4FNO/c8-7-2-1-6(10)3-5(7)4-9/h1-3,10H

Upstream product

• 127667-01-0 2-fluoro 5-methoxybenzonitrile 
• 42539-98-0 4,4-difluorocyclohexa-2,5-dienone 
• 108-95-2 phenol 
• 71-43-2 benzene 
• 151-50-8 potassium cyanide 

Downstream Products

• 1092778-83-0 5-(benzyloxy)-2-fluorobenzonitrile 
• 1236857-62-7 2-fluoro-5-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile 
• 1441256-80-9 5-ethoxy-2-fluorobenzonitrile 
• 38711-08-9 6-benzyloxy-quinazoline-2,4-diamine 
• 1092778-58-9 2,4-diaminoquinazolin-6-yl 2,5-dimethoxybenzoate 
• 1351989-79-1 2-fluoro-5-(2,2,2-trifluoro-ethoxy)-benzonitrile 

Relevant academic research and scientific papers

2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES

A compound of formula (I) wherein X is NH2or OH and W is -C(O)-O- or -O-C(O)-; use thereof as a medicament, in particular for the treatment of inflammation, autoimmune disorder, immunogenic rejection reactions and cancer and for non-surgical abortion.

Preparation of 3-cyano-4-fluorophenol

The invention provides a process for the preparation of 4-fluorophenols of formula STR1 wherein n is 0 to 3, each R independently represents a halogen atom or an alkyl, alkoxy, cyano or optionally substituted amino group and Z represents a hydrogen or halogen atom or a cyano group characterized by reacting a fluorohalocyclohexadienone of formula STR2 wherein X represents a halogen atom, with a compound of formula A-Z, wherein Z is as defined above and A represents a hydrogen or alkali metal atom, provided that when both A and Z are hydrogen, the reaction is carried out in the additional presence of a Group VIII metal hydrogenation catalyst, and 4-fluorophenols of formula I per se wherein Z is a CN group.