10480-53-2

Upstream product

• 1456-22-0 3-phenyl-4H-[1,2,4]oxadiazol-5-one 
• 3201-46-5 4-methyl-3-phenyl-1,2,4-oxadiazol-5(4H)-one 
• 100-39-0 benzyl bromide 
• 3488-55-9 N-hydroxy-N'-(phenylmethyl)-benzenecarboximidamide 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 3488-55-9 N-hydroxy-N'-(phenylmethyl)-benzenecarboximidamide 

Relevant academic research and scientific papers

Tf2NH-catalyzed formal [3 + 2] cycloaddition of oxadiazolones with ynamides: a simple access to aminoimidazoles

Oxadiazolones are first employed as the three-atom coupling partners in the Tf2NH-catalyzed cycloaddition with ynamides. This formal [3 + 2] cycloaddition allows a rapid synthesis of aminoimidazoles with a broad substrate scope. The approach also features a metal-free catalytic cycloaddition process, which may find applications in the synthesis of bioactive molecules. Besides, the resulting N-methyl products can further be readily converted to free N-H aminoimidazoles.