104800-03-5Relevant articles and documents
Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers
Piplani, Poonam,Danta, Chhanda Charan
, p. 64 - 73 (2015/05/20)
A series of novel hybrids has been designed, synthesized and evaluated for cognition enhancing activities through the inhibition of acetylcholinesterase (AChE) and by passive avoidance mouse model. All the compounds showed excellent AChE inhibition activi
Two new phenylpiperazines with atypical antipsychotic potential
Tomic, Mirko,Ignjatovic, Djurdjica,Tovilovic, Gordana,Andric, Deana,Roglic, Goran,Kostic-Rajacic, Sladjana
, p. 5749 - 5753 (2008/09/21)
Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and αsu
Synthesis of 4-(1-oxo-isoindoline)-, 4-(5,6-dimethoxy-1-oxo-isoindoline) and 4-acetamido-substituted phenoxy-3-amino-propane derivatives and their β1-, β2- adrenergic receptor binding studies
Jindal, Dharam Paul,Singh, Babita,Sharma, Neelam,Coumar, Mohane S.,Bruni, Giancarlo,Massarelli, Paola
, p. 2808 - 2813 (2007/10/03)
In continuation to our previous study of 4-(1-oxo-isoindoline)- and 4-(5,6-dimethoxy-l-oxo-isoindoline)-substituted phenoxypropanolamines as potential cardioselective β-adrenergic blocking agents, the synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethox
Synthesis and SAR in 1-aryloxy-3-(4-arylpiperazin-1-yl)propanes
Tripathi, R. C.,Dua, P. R.,Srimal, R. C.,Saxena, Anil K.
, p. 116 - 119 (2007/10/02)
1--3-(4-arylpiperazin-1-yl)propanes (7-11), 1-(3/4-acetamino/aminophenoxy)-3-(4-arylpiperazin-1-yl)propanes (12-32) have been synthesized and evaluated for their CNS, CVS and antiinflammatory activities.The compounds, in gen
Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment
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, (2008/06/13)
A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.
Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds
Walsh, David A.,Franzyshen, Stephen K.,Yanni, John M.
, p. 105 - 118 (2007/10/02)
A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.
DIPHENIC ACID MONOAMIDES
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, (2008/06/13)
The present invention provides various novel diphenic acid monoamide compounds, novel pharmaceutical compositions and methods of use thereof, as well as novel methods of synthesis therefor. The novel diphenic acid monoamides of the present invention are l
