104801-82-3

Basic information

• Product Name: 2-Hexyl-5-hydroxy-3-oxo-hexadecanoic Acid Methyl Ester
• Synonyms: 2-Hexyl-5-hydroxy-3-oxo-hexadecanoic Acid Methyl Ester
• CAS NO: 104801-82-3
• Molecular Formula: C23H44O4
• Molecular Weight: 384.59306
• Product Categories: Aliphatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 104801-82-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 478.9±20.0 °C(Predicted)
• Appearance: /
• Density: 0.944±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Ethyl Acetate, Tetrahydrofuran
• PKA: 11.62±0.59(Predicted)
• CAS DataBase Reference: 2-Hexyl-5-hydroxy-3-oxo-hexadecanoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexyl-5-hydroxy-3-oxo-hexadecanoic Acid Methyl Ester(104801-82-3)
• EPA Substance Registry System: 2-Hexyl-5-hydroxy-3-oxo-hexadecanoic Acid Methyl Ester(104801-82-3)

Safety Data

• Hazardous Substances Data: 104801-82-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

2-Hexyl-5-hydroxy-3-oxo-hexadecanoic Acid Methyl Ester is a reactant used in the preparation of oxetanone derivatives as lipase inhibitors and potential anti-obesity compounds such as tetrahydrolipstatin.

Upstream product

• 252727-27-8 7-carbomethoxy-8-hydroxy-10-tert-butyldimethylsilyloxyheneicosane 
• 76828-23-4 (4RS)-1-pentadecen-4-ol 
• 112-54-9 Dodecanal 
• 252727-28-9 7-carbomethoxy-8-oxo-10-tert-butyldimethylsilyloxyheneicosane 
• 70203-04-2 2-acetyl-octanoic acid methyl ester 
• 252727-26-7 4-tert-butyldimethylsilyloxypentadec-1-ene 
• 213459-08-6 3-tert-butyldimethylsilyloxytetradecanal 
• 5445-22-7 methyl 2-bromooctanoate 
• 2623-82-7 2-bromooctanoic acid 
• 112-53-8 1-dodecyl alcohol 

Downstream Products

• 1225451-00-2 (R)-1'-<((2''R,3''R)-3''-hexyl-4''-oxo-2''-oxetanyl)methyl>dodecyl (S)-N-formylleucinate 
• 1225451-00-2 (S)-1-((2R,3R)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl formyl-L-leucinate 
• 1225451-00-2 (R)-1'-<((2''S,3''S)-3''-hexyl-4''-oxo-2''-oxetanyl)methyl>dodecyl (S)-N-formylleucinate 
• 104801-93-6 2-hexyl-3-hydroxy-5-<(tetrahydro-2H-pyran-2-yl)oxy>hexadecanoic acid 
• 104872-04-0 Orlistat 
• 160549-09-7 3-hexyl-3,4,5,6-tetrahydro-4β-hydroxy-6-undecyl-2H-pyran-2-one 
• 104801-67-4 methyl-2-hexyl-3-oxo-5-<(tetrahydro-2H-pyran-2-yl)oxy>hexadecanoate 

Relevant articles and documents

Enzymatic lactonization stategy for enantioselective synthesis of a tetrahydrolipstatin synthon

A novel lipase-catalyzed protocol has been formulated for the simultaneous enantiocontrol of three stereogenic centers in a flexible acyclic system. This involved a porcine pancreatic lipase (PPL)-catalyzed δ- lactonization of a racemic 3,5-dihydroxy-2-alkyl ester to produce the lactone with high enantioselectivity (92.8%). The product lactone and its analogues are useful synthons for the asymmetric synthesis of various bioactive compounds, which include the potential anti-obesity compound, tetrahydrolipstatin.

OXETANONES

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