104874-86-4

Basic information

• Product Name: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, (S)-
• Synonyms: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, (S)-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]carbonyl]-
• CAS NO: 104874-86-4
• Molecular Formula: C23H25 N5 O5
• Molecular Weight: 451.48
• Mol File: 104874-86-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, (S)-(104874-86-4)
• EPA Substance Registry System: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, (S)-(104874-86-4)

Safety Data

• Hazardous Substances Data: 104874-86-4(Hazardous Substances Data)

Usage

Uses

(S)-(+)-Doxazosin is an Isomer of Doxazosin Mesylate (D537500) a selective α1-adrenoceptor antagonist. Doxazosin relaxes smooth muscles of the prostate.

Upstream product

• 62501-71-7 (R)-2-benzyloxymethyl-2,3-dihydrobenzodioxane 
• 62501-72-8 (R)-2-hydroxymethyl-1,4-benzodioxane 
• 1415584-44-9 (S)-N-Boc-(1,4-benzodioxan-2-carbonyl)piperazine 
• 23680-84-4 2-chloro-6,7-dimethoxyquinazolin-4-amine 
• 401941-54-6 (S)-N-(1,4-benzodioxan-2-carbonyl)piperazine 
• 62501-71-7 (S)-2-benzyloxymethyl-2,3-dihydrobenzodioxane 
• 98572-00-0 (S)-2-hydroxymethyl-1,4-benzodioxane 
• 70918-53-5 (+)-(2R)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid 
• 1219800-50-6 (R)-tert-butyl 4-(2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)piperazine-1-carboxylate 
• 860173-98-4 (R)-N-(1,4-benzodioxan-2-carbonyl)piperazine 
• 533-58-4 2-Iodophenol 
• 70918-00-2 (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone 
• 3663-80-7 1,4-benzodioxane-2-carboxylic acid 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 

Downstream Products

• 156154-10-8 doxazosin mesylate 
• 156154-10-8 doxazosin mesylate 

Relevant articles and documents

A reliable multigram synthesis of (±) doxazosin

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Method for synthesizing doxazosin

The invention discloses a method for synthesizing doxazosin and belongs to the technical field of chemical synthesis. According to the method, the doxazosin is synthesized by adopting a synthesis route, represented by formulae shown in the description, different from the conventional technologies, and thus a novel synthesis route is provided for preparing the doxazosin; and the method has the advantages of moderate conditions, simple and convenient steps and high yield, and the doxazosin can be obtained simply and efficiently.

Process for the Preparation of Doxazosin and Salts Thereof

The present invention relates to a process for the preparation of doxazosin or salts thereof.

THERAPY FOR COMPLICATIONS OF DIABETES

A method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome comprises administering to the subject a selective endothelin A (ETA) receptor antagonist in a glycemic control and/or insulin sensitivity enhancing effective amount. A method for treating a complex of comorbidities in an elderly diabetic human subject comprises administering to the subject a selective ETA receptor antagonist in combination or as adjunctive therapy with at least one additional agent that is (i) other than a selective ETA receptor antagonist and (ii) effective in treatment of diabetes and/or at least one of said comorbidities other than hypertension. A therapeutic combination useful in such a method comprises a selective ETA receptor antagonist and at least one antidiabetic, anti-obesity or antidyslipidemic agent other than a selective ETA receptor antagonist.