104875-64-1Relevant articles and documents
Cycloadditions of siloxy alkynes with 1,2-diazines: From reaction discovery to identification of an antiglycolytic chemotype
Montavon, Timothy J.,Tuerkmen, Yunus E.,Shamsi, Noumaan A.,Miller, Christopher,Sumaria, Chintan S.,Rawal, Viresh H.,Kozmin, Sergey A.
supporting information, p. 13576 - 13579 (2014/01/06)
Cycloaddition uncovered: The title reaction produces novel polycyclic compounds with high efficiency and excellent diastereoselectivity under mild reaction conditions. A small-molecule library, synthesized using this reaction, yielded a novel chemotype which inhibited glycolytic ATP production by blocking glucose uptake in CHO-K1 cells. DMF=N,N-dimethylformamide, Tf= trifluoromethanesulfonyl, TIPS=triisopropylsilyl. Copyright
Silver-catalyzed hydroamination of siloxy alkynes
Sun, Jianwei,Kozmin, Sergey A.
, p. 4991 - 4993 (2007/10/03)
(Chemical Equation Presented) New catalytic process: The silver-catalyzed hydroamination of siloxy alkynes with secondary amides furnishes silyl ketene aminals with high efficiency and excellent diastereoselectivity (see scheme), including some that are unavailable by conventional silylation methods. The reaction comprises a fast and reversible silver-alkyne complexation, followed by a rate-determining C-N bond-forming step.
TRIALKYLSILYLOXYALKINES: SYNTHESIS AND AROMATIC ANNULATION REACTIONS
Danheiser, Rick L.,Nishida, Atsushi,Savariar, Selvaraj,Trova, Michael P.
, p. 4917 - 4920 (2007/10/02)
Substitued resorcinols are produced by the thermal addition of cyclobutenones to trialkylsilyloxyalkines.The dehydrobromination of (Z)-2-bromovinyl silyl ethers has been employed in the first synthesis of trialkylsilyloxyethyne derivatives.
