125783-07-5Relevant academic research and scientific papers
A highly stereoselective synthesis of tri- and tetrasubstituted olefins via ynolates
Shindo, Mitsuru,Sato, Yusuke,Shishido, Kozo
, p. 4857 - 4860 (1998)
A highly stereoselective synthesis of tri- and tetrasubstituted olefins has been accomplished by the reactions of ynolates with aldehydes and ketones.
Ni-Catalyzed Regioselective Hydrocarboxylation of Alkynes with CO2 by Using Simple Alcohols as Proton Sources
Wang, Xueqiang,Nakajima, Masaki,Martin, Ruben
supporting information, p. 8924 - 8927 (2015/08/03)
A mild and user-friendly Ni-catalyzed regioselective hydrocarboxylation of alkynes with CO2 (1 bar) is described. This protocol is characterized by a wide scope while obviating the need for sensitive organometallic species and by an unprecedented regioselectivity pattern using simple alcohols as proton sources.
Highly E-selective synthesis of α,β-unsaturated amides from N-2- methoxyphenyl aldimines via lithium ynolates
Shindo, Mitsuru,Oya, Soichiro,Murakami, Ryoko,Sato, Yusuke,Shishido, Kozo
, p. 5947 - 5950 (2007/10/03)
Lithium ynolates reacted with N-2-methoxyphenyl (OMP) aldimines to afford α,β-unsaturated amides in excellent E-selectivity via a retro- Mannich reaction of the 2:1 adducts (β-lactams), followed by cleavage of the β-lactam enolates. (C) 2000 Elsevier Science Ltd.
Trisubstituted Olefins via Ester-Derived (Silyloxy)acetylenes: A Highly Stereoselective Alternative to the Horner-Wadsworth-Emmons Reaction
Kowalski, Conrad J.,Sakdarat, Santi
, p. 1977 - 1979 (2007/10/02)
Crude ((triisopropylsilyl)oxy)acetylenes 2, prepared in one step from common esters 1, react with aldehydes in 60-65 percent overall yield after methanol quench to afford α,β-unsaturated esters 3 with very high E/Z stereoselectivity.
